Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares cardiac MRI–derived microstructural tissue phenotypes in adults with cardiovascular disease to those in healthy controls. It uses novel MRI methods that exploit endogenous tissue properties to characterize inflammation, fibrosis, metabolism, and microstructure of the heart. Participants may undergo an extended clinical cardiac MRI or a research non-contrast MRI protocol, with follow-up of medical status for up to five years. The goal is to determine how microstructure relates to heart structure and function and to inform the development of faster, more robust cardiac MRI exams for clinical use. Interventions are not randomized and all procedures are imaging-based.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years of age
* Provision of written informed consent

Exclusion Criteria:

* Vulnerable populations will be excluded from this study including Prisoners
* Other contraindications to CMR imaging to be determined by standard MRI protocols
* Decisionally impaired (e.g., dementia or cognitive disability)

Where it's running

• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting

Study contacts

• Study coordinator: Research Coordinator Research Coordinator
• Email: CIRC@ccf.org
• Phone: 216-445-6515

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.