Altered lymphatic function in congenital heart disease
Official title: Altered Lymphatic Function and Development in Congenital Heart Disease
Funded at University of California, San Francisco · NIH-11350882 · Data updated 2026-11-12
A study in people and animal models examines how congenital heart disease affects the lymphatic system and its role in related health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 1, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $680,952 |
| NIH project number | 5R01HL133034-10 |
| Project ID | NIH-11350882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants include individuals with congenital heart disease and related lymphatic or pulmonary complications, as well as those who could contribute tissue samples or data.
✕Less likely to help
Patients without CHD-related lymphatic or pulmonary complications may have limited direct benefit.
What this research studies
This project investigates how abnormal lymphatic structure and function contribute to morbidity in congenital heart disease (CHD) by studying lymphatic flow, architecture, and cellular signaling in models that mimic CHD. Using a large animal CHD model and cultured lymphatic endothelial cells, researchers look at how increased pulmonary blood flow changes the lymphatic system, mitochondrial reactive oxygen species, and NO signaling. The goal is to understand the pathobiology so future therapies can improve respiratory outcomes and survival in CHD patients.
Why it matters
Potential benefit: Findings could lead to new treatments that reduce lung complications and improve quality of life for people with CHD.
How similar studies have gone: Previous work in CHD models suggests lymphatic changes play a role in disease progression, making this a promising but still early area of study.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Datar, Sanjeev a. — University of California, San Francisco
- Study coordinator: Datar, Sanjeev a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.