Lymphatic Changes in Congenital Heart Disease
Official title: Altered Lymphatic Function and Development in Congenital Heart Disease
Funded at University of California, San Francisco · NIH-11091476 · Data updated 2026-11-12
This project looks at how lymphatic vessels develop and function differently in people with congenital heart disease, especially those with increased blood flow to the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 1, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $694,850 |
| NIH project number | 5R01HL133034-09 |
| Project ID | NIH-11091476 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational work focuses on understanding disease mechanisms in congenital heart disease, particularly those affecting the lymphatic system in both children and adults.
✕Less likely to help
Patients without congenital heart disease or related lymphatic issues would not directly benefit from this specific research.
What this research studies
Many health issues in congenital heart disease, like fluid buildup in the chest or immune problems, are linked to changes in the body's lymphatic system. Even after heart surgery, breathing problems can continue for years and increase risks for adults with congenital heart disease. This project aims to understand why these lymphatic changes happen and how they contribute to the disease. Researchers are using advanced models to explore how increased blood flow to the lungs affects lymphatic vessels, their structure, and their cellular processes.
Why it matters
Potential benefit: Understanding these lymphatic changes could lead to new ways to prevent or treat complications and improve long-term health for patients with congenital heart disease.
How similar studies have gone: This project builds upon previous findings in animal models that have shown specific lymphatic abnormalities linked to increased pulmonary blood flow in congenital heart disease.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Datar, Sanjeev a. — University of California, San Francisco
- Study coordinator: Datar, Sanjeev a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.