Condition

Single-ventricle clinical trials and research

• 13Clinical trials
• 13NIH research projects
• 1New in 30 days
• 8Countries

Newest Single-ventricle clinical trials

All recruiting trials (13)

• Long-term safety follow-up after autologous cardiac stem cells in kids with single ventricle heart disease

  This study checks whether autologous cardiac stem cells (JRM-001) remain safe for up to a year in children who already received them after heart reconstructive surgery.

  Recruiting Metcela Inc. · Okayama, Okayama-ken · NCT07884318

• Venous Compression for Fontan Patients

  This study tests whether wearing lower-extremity compression garments can increase exercise stroke volume in people with Fontan circulation.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07220226

• Starting Fortini after the first heart surgery to help infants with single-ventricle defects grow better

  This trial will see if giving Fortini, a high-calorie low-osmolality formula, at hospital discharge helps infants with single-ventricle heart defects gain more weight before their next surgery.

  Recruiting Driscoll Children's Hospital · Corpus Christi, Texas · NCT07087782

• Fontan conduit stenting to lower liver stiffness and improve exercise capacity

  This project will see if placing a stent in an extracardiac Fontan conduit changes liver stiffness and exercise capacity in 12–21-year-olds with single-ventricle Fontan palliation.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT07073612

• Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease

  This study is trying to see if a new type of diabetes medication can help adults with congenital heart disease feel better and manage their heart failure symptoms.

  Recruiting at 11 sites Leiden University Medical Center · Baltimore, Maryland and 10 other locations · NCT06932081

• Improving fitness for adolescents with the Fontan circulation

  This study will test whether a home-based digital exercise program helps 10–17-year-olds with the Fontan circulation become more active and improve fitness compared with enhanced usual care.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06918795

• Integrated prenatal and postnatal treatment for newborns with critical congenital heart disease

  This study is testing a new approach that combines care before and after birth for newborns with serious heart defects to see if it can improve their treatment and recovery.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT06768008

• Profiling micro RNA in newborns with congenital heart disease

  This study is trying to understand how certain molecules in the blood of newborns with severe congenital heart disease affect their risk of blood clots during surgery.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06434207

• Cardiac rehabilitation for patients with Fontan failure

  This study tests if a cardiac rehabilitation program can help adults with Fontan failure feel better and improve their daily activities compared to regular care.

  Recruiting at 2 sites Stanford University · Stanford, California and 1 other locations · NCT06150950

• Assessing heart function in children with single-ventricle congenital heart disease

  This study is testing a new 3D heart imaging technique to see if it can better measure heart size and function in children and young adults with a specific type of heart defect compared to the standard MRI method.

  Recruiting Duke University · Durham, North Carolina · NCT05262907

• Evaluating a new type of vascular graft for heart surgery in children

  This study is testing a new type of heart surgery graft for children to see if it is safe and works well for their needs.

  Recruiting Phase 2 Nationwide Children's Hospital · Columbus, Ohio · NCT04467671

• Monitoring oxygen levels in newborns with congenital heart defects

  This study is testing a new way to monitor oxygen levels in newborns with congenital heart defects to see how it can help doctors understand their heart and blood flow better.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04106479

• Infusing a child's own heart stem cells during single-ventricle surgery (APOLLON)

  This trial will try injecting a child's own cardiac stem/progenitor cells into the coronary arteries after Glenn or Fontan surgery to help children with a functional single ventricle and reduced ejection fraction.

  Recruiting at 4 sites Phase 3 Metcela Inc. · Kanagawa and 3 other locations · NCT02781922

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Senescent cells in single-ventricle heart disease

  The team is looking at how aged support cells in the heart may lead to heart failure in people born with a single working ventricle.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11445191

• Bioprinted vascular grafts to help children and adults with single-ventricle heart defects

  A new bioprinting approach aims to create patient-specific, tissue-like vascular conduits that can repair damaged heart vessels and improve blood flow for people with single-ventricle defects.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11415468

• Lipid damage and mitochondria: new ways to protect the Fontan heart

  A Stanford-led study aims to find new targets and biomarkers to preserve heart function in children with Fontan circulation by looking at how oxidative stress damages heart cell powerhouses and affects blood vessels.

  NIH research Stanford University · Stanford, United States · NIH-11330408

• Off-the-shelf living blood vessel grafts for children with single-ventricle heart defects

  This work is making ready-to-use living blood vessel grafts from donated umbilical arteries and engineered stem-cell lining to help children born with single-ventricle heart defects.

  NIH research Yale University · New Haven, United States · NIH-11228764

• Investigating how mitochondrial injury affects blood vessel function in children with congenital heart disease.

  This study is looking at how heart failure affects children who have had a special heart surgery called the Fontan operation, with the goal of finding new ways to spot heart problems early and improve treatments for them.

  NIH research Stanford University · Stanford, United States · NIH-11083653

• Digoxin effects in infants with single‑ventricle heart failure

  This project looks at how the heart drug digoxin behaves and affects newborns and infants who have heart failure from single‑ventricle congenital heart disease.

  NIH research Duke University · Durham, United States · NIH-11045660

• Investigating heart failure in patients with congenital heart disease

  This study is looking at Single Ventricle Disease, a serious heart condition, to find out what causes heart failure in people with this disease, and it hopes to create better treatments to help improve heart health for those affected, including patients who may share their samples or information to support the research

  NIH research Texas Heart Institute · Houston, United States · NIH-11040756

• Investigating treatments for single ventricle heart disease

  This study is looking at the special challenges young adults with single ventricle congenital heart disease face as they grow up, and it aims to find better treatments for heart failure that are specific to their needs.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11004040

• Investigating blood flow development in children with single ventricle heart disease

  This study is looking at how heart surgery affects the growth of blood vessels in the lungs of children with single ventricle heart disease, by checking their blood and using special imaging to help understand what helps them do better or worse after surgery.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11002340

• Using engineered blood vessels to treat heart defects in children

  This study is working on a new way to help kids with single ventricle heart defects by creating special blood vessels that can grow with them, using safe materials from human umbilical cords, to make their surgeries more successful.

  NIH research Yale University · New Haven, United States · NIH-10991036

• Investigating digoxin's effects on infants with heart failure from congenital heart disease

  This study is looking at how the heart medicine digoxin works in babies with heart failure caused by a specific heart condition, hoping to find better ways to help these little ones feel better and live healthier lives.

  NIH research Duke University · Durham, United States · NIH-10807963

• Investigating brain health in children with single ventricle heart disease

  This study is looking at how single ventricle heart disease impacts the brain health of kids and teens, exploring how blood flow and certain brain chemicals might affect their thinking skills, with the goal of finding ways to help them do better in school and everyday life.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10772179

• Investigating the effects of Fontan surgery on heart and liver health in patients with single ventricle conditions.

  This study is looking at how the Fontan surgery affects the hearts and livers of patients with congenital heart disease, and it’s also testing a medication called spironolactone to see if it can help reduce scarring in these organs after the surgery.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10676308

Related topics

Quick answers

How many Single-ventricle clinical trials are recruiting right now?

13, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (9 trials), Japan (2 trials), China (1 trial), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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