Metabolic Changes Driving Pulmonary Vessel Disease in Congenital Heart Disease with New Collagen Pathway
Official title: METABOLIC REPROGRAMMING AND PULMONARY VASCULAR DISEASE ASSOCIATED WITH CONGENITAL HEART DISEASE RESULTING IN INCREASED PULMONARY BLOOD FLOW
Funded at Florida International University · NIH-11401950 · Data updated 2026-11-12
This grant studies how metabolic changes in the lungs of children with congenital heart disease and high blood flow may lead to damaging blood vessel changes, with a focus on a collagen pathway.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 10, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,227,228 |
| NIH project number | 5P01HL146369-08 |
| Project ID | NIH-11401950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with congenital heart disease who have increased pulmonary blood flow and related vascular issues.
✕Less likely to help
Findings may not directly benefit children without CHD or with normal pulmonary blood flow.
What this research studies
In kids born with certain heart defects, increased blood flow to the lungs can cause dangerous remodeling of lung vessels. The project looks at how metabolism shifts, especially proline and collagen production, influence endothelial cells and their tendency to multiply and resist death. By studying a pig or lamb model and human samples, researchers aim to link these metabolic changes to the development of pulmonary vascular disease. The work seeks to identify targets that could later guide therapies to protect the lungs of affected patients.
Why it matters
Potential benefit: If successful, the research could reveal new metabolic targets to prevent or lessen pulmonary vascular disease in children with CHD, potentially improving long-term lung and heart health.
How similar studies have gone: Previous studies show that metabolic changes can influence vascular remodeling; this proposal builds on that by exploring a specific proline-collagen pathway in the endothelium.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.