Condition

Cardiomyopathies clinical trials and research

• 39Clinical trials
• 15NIH research projects
• 1New in 30 days
• 28Countries

Newest Cardiomyopathies clinical trials

All recruiting trials (39)

• Myocardial Energetics Across Cardiovascular Disease Spectrum Using 31P-MRS

  Researchers are testing whether phosphorus-31 magnetic resonance spectroscopy (31P-MRS) can map heart energy metabolism across healthy people and patients with various heart conditions.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07912086

• Liver and Coagulation Markers in ATTR Cardiac Amyloidosis

  This study tests liver function and blood-clotting markers in people with ATTR-CA to see if they reflect disease severity and progression.

  Recruiting University of Messina · Messina, Sicily · NCT07766135

• RHYthm and Myocardial Function Relationship in Heart Disease

  This study tests how heart rhythm patterns relate to heart muscle function in adults with arrhythmias or cardiomyopathy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07491237

• Multimodal analysis of heart biopsy samples

  This project will take one extra small heart biopsy during a clinically needed procedure to test whether detailed molecular and immune analyses can find disease-specific signatures in adults with cardiomyopathies, myocarditis, cardiac amyloidosis, or after heart transplant.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07359690

• Electrophysiological mapping to predict sudden cardiac death risk

  It will test whether detailed electrical mapping of the left ventricle can better predict dangerous ventricular arrhythmias in adults with ischemic or non-ischemic cardiomyopathy and LVEF under 50% who are not already ICD candidates.

  Recruiting at 3 sites University Hospital, Bordeaux · Clermont-Ferrand and 2 other locations · NCT07020702

• Using retinal photographs to assess cardiovascular disease risk in heart failure patients

  This study is testing if looking at retinal photographs can help predict the risk of heart problems in people who have recently been diagnosed with heart failure.

  Recruiting Yonsei University · Seoul · NCT06978998

• Using flecainide to treat frequent premature ventricular contractions and related heart issues

  This study is testing if the heart medication flecainide can help adults with frequent heartbeats and related heart issues who can't or don't want to have a procedure called catheter ablation.

  Recruiting at 3 sites University of Athens · Pátrai, Achaia and 5 other locations · NCT06949748

• Effects of melatonin on heart health in patients with cardiomyopathy

  This study tests if melatonin can help improve heart health in adults with cardiomyopathy while they continue their usual medications.

  Recruiting Phase 3 Tanta University · Dakahlia, Egypt, Mansoura · NCT06846086

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Natural history of PKP2-related arrhythmogenic cardiomyopathy

  This project will collect past and ongoing health information to see how PKP2-related arrhythmogenic cardiomyopathy progresses in people managed with standard care.

  Recruiting at 2 sites Rocket Pharmaceuticals Inc. · Boston, Massachusetts and 2 other locations · NCT06644742

• Study of heart conditions using advanced imaging techniques

  This study is trying to find out what causes different heart conditions in Hispanic and African American people in the Bronx by using advanced imaging techniques.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06610019

• Evaluating endomyocardial biopsy and tailored treatments for pediatric inflammatory heart disease

  This study is testing how a heart tissue sample and personalized treatments can help kids with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT06591260

• Observing heart function recovery after bypass surgery with a wearable defibrillator

  This study is testing if using a wearable defibrillator after heart bypass surgery can help patients with weak heart function recover better than before.

  Recruiting at 3 sites Zoll Medical Corporation · Bad Nauheim, Hesse and 3 other locations · NCT06570902

• Preventing transthyretin amyloidosis in young carriers of a genetic variant

  This study is testing if a medication called acoramidis can help prevent transthyretin amyloidosis in young adults who carry a specific genetic variant that puts them at risk for the disease.

  Recruiting at 104 sites Phase 3 Eidos Therapeutics, a BridgeBio company · La Jolla, California and 103 other locations · NCT06563895

• Investigating biomarkers in patients with genetic cardiomyopathy

  This study is trying to find new markers in blood and other tests to help identify people with a family history of genetic heart disease who might develop symptoms, so they can be monitored more easily and effectively.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT06446271

• Biobank of stem cells and biomarkers for cardiovascular disease

  This study is creating a bank of stem cells and blood samples from people with heart disease to help researchers learn more about the condition and find better treatments.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06371937

• Stereotactic body radiation therapy versus catheter ablation for ventricular tachycardia in structural heart disease

  This trial will test whether a focused radiation treatment (SBRT) can reduce ventricular tachycardia episodes more than standard catheter ablation in people with advanced structural heart disease.

  Recruiting Western Sydney Local Health District · Westmead · NCT06360939

• Improving prevention and treatment strategies for cardiomyopathy patients

  This study is trying to gather information from cardiomyopathy patients to find better ways to prevent and treat their condition.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06352320

• Colchicine treatment for chronic inflammatory cardiomyopathy

  This study tests if colchicine can help people with chronic inflammatory cardiomyopathy who have heart issues feel better by reducing inflammation in their hearts.

  Recruiting at 10 sites Phase 3 Niguarda Hospital · Naples, Campania and 9 other locations · NCT06158698

• Cardiohelp ECMO support for children with severe cardiac failure

  This study will test the Cardiohelp VA-ECMO system for up to 30 days and try heparin versus bivalirudin as anticoagulants in children (0–16 years) with severe heart failure who need VA-ECMO.

  Recruiting at 5 sites Phase 2 Stanford University · Palo Alto, California and 4 other locations · NCT06080074

• Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics

  This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06001073

• Using echocardiograms and patient data to diagnose cardiac diseases

  This study is testing if using advanced technology to analyze heart ultrasound images along with patient information can help doctors better diagnose heart diseases.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT05942729

• AI analysis of ECGs for high-risk cardiac patients

  This study is testing an AI tool that analyzes heart rhythm patterns in high-risk heart patients to see if it can help doctors catch problems earlier and improve patient care.

  Recruiting at 2 sites Idoven 1903 S.L. · Groningen, Provincie Groningen and 12 other locations · NCT05890716

• Evaluating a non-invasive method for cardiac resynchronization therapy

  This study tests a new non-invasive device to see how well cardiac resynchronization therapy works for people with heart failure and left bundle branch block during their treatment.

  Recruiting Oslo University Hospital · Oslo · NCT05868616

• Observing the causes and progression of cardiomyopathy

  This study is trying to understand what causes cardiomyopathy and how it gets worse by collecting DNA, blood samples, and health information from people with the condition or those at risk.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT05750147

• Evaluating the safety of endocardial myocardial biopsy procedures

  This study is testing the safety of a heart tissue biopsy procedure for patients with heart issues like myocarditis and cardiomyopathies to see how well it works and what risks it might have.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05718128

• Gene therapy for heart issues in Friedreich's ataxia

  This study is testing a new gene therapy for heart problems in people with Friedreich's ataxia to see if it is safe and helps improve their heart function.

  Recruiting Phase 1 Weill Medical College of Cornell University · New York, New York · NCT05302271

• Hypertrophic Cardiomyopathy Registry, Biobank, and Imaging Data Repository

  This project tests whether collecting genetic, imaging, and clinical data from people with hypertrophic cardiomyopathy can help predict outcomes and better understand the disease.

  Recruiting at 15 sites Montreal Heart Institute · Edmonton, Alberta and 16 other locations · NCT05100420

• Investigating VTA Ablation in Patients with Left Ventricular Assist Devices

  This study is testing if a procedure to stop fast heartbeats during surgery for a heart pump can help patients with a history of those fast heartbeats feel better after the surgery.

  Recruiting at 19 sites Phase 4 University of Rochester · Phoenix, Arizona and 18 other locations · NCT05034432

• Registry for monitoring heart conditions

  This study is collecting health information from people with heart symptoms to see if it can help doctors catch heart problems earlier and understand them better.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT04976348

• Using PPG to Predict Heart Function in the General Population

  This study is testing if a wristband can help predict heart function in adults by comparing its readings with traditional heart scans.

  Recruiting at 3 sites Tulane University · New Orleans, Louisiana and 2 other locations · NCT04843371

• Noninvasive monitoring of heart function in patients with LVADs

  This study is testing new ways to monitor heart function in people with a HeartMate 3 LVAD to see if they can get better information than the usual methods like echocardiograms and ECGs.

  Recruiting Medical University of Vienna · Vienna · NCT04641416

• Registry for patients with cardiomyopathy and myocarditis

  This study is trying to gather health information from people with cardiomyopathy or myocarditis to better understand these conditions and their genetics.

  Recruiting Imperial College London · London · NCT04612296

• Evaluating endomyocardial biopsy and tailored treatments for inflammatory heart disease

  This study is trying to see if a heart tissue test and personalized treatments can help people with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT04521790

• Identifying Risk Factors for Heart Toxicity from Immune Checkpoint Inhibitors

  This study is trying to find out what factors might increase the risk of heart problems in people receiving immune checkpoint inhibitors for cancer treatment.

  Recruiting Groupe Hospitalier Pitie-Salpetriere · Paris · NCT04294771

• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

  This study is trying to gather information and samples from people with arrhythmogenic ventricular cardiomyopathy and their families to better understand the genetic causes of the condition and improve early diagnosis for those at risk.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT03049254

• Identifying genetic causes of heart issues in epilepsy patients

  This study is trying to find out if certain genetic factors can help explain why some young adults with epilepsy are at risk for sudden death.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02824822

• Analyzing genetic mutations in pediatric cardiomyopathy

  This study is trying to learn more about the genetic causes of heart problems in children with cardiomyopathy to help improve diagnosis and treatment options for them.

  Recruiting Indiana University · Indianapolis, Indiana · NCT02432092

• Observational study on heart defibrillators for preventing sudden cardiac death

  This study looks at patients with heart defibrillators to see what factors might increase the risk of sudden cardiac death and how to better choose who needs these devices.

  Recruiting at 4 sites Johns Hopkins University · Washington D.C., District of Columbia and 3 other locations · NCT00733590

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Inflammatory and Genetic Heart Disease: Using Metabolic Clues to Guide Diagnosis and Therapy

  Aims to improve diagnosis and treatment decisions for people with complex heart muscle diseases by combining metabolic data, genetics, and advanced imaging.

  NIH research University of Washington · Seattle, United States · NIH-11378198

• Biological Basis of cMyBP-C Cardiomyopathies and How Variants Cause Disease

  This grant studies how genetic changes in a heart protein called cMyBP-C lead to cardiomyopathy, aiming to connect a person’s specific variant to their risk and potential therapies.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11345931

• Bait-and-switch gene therapy for heart muscle diseases

  A heart-focused gene therapy approach uses AAV vectors redirected to the heart to treat conditions like hypertrophic cardiomyopathy.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11343872

• How extra calcium in heart cell powerhouses affects mitochondrial heart disease in children

  This project looks at whether increased calcium entry into mitochondria helps heart cells make more energy in children with mitochondrial cardiomyopathy.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11332250

• Genetic heart muscle problems: how tiny changes in muscle proteins affect your heart

  A research study from the University of Washington aims to understand how genetic changes in heart muscle proteins affect heart function and how to predict which patients might respond to future treatments.

  NIH research University of Washington · Seattle, United States · NIH-11324562

• How mutations affect heart muscle function at the tiny level

  Researchers are studying how heart muscle proteins interact at the smallest scale to understand why certain genetic changes lead to heart muscle disease.

  NIH research University of Arizona · Tucson, United States · NIH-11269393

• Thin-filament heart muscle disease: causes and ways to block it

  This project looks at how small changes in heart muscle proteins cause inherited cardiomyopathy and seeks ways to stop those changes from damaging the heart.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11242014

• Mimicking fasting effects to treat heart muscle diseases

  This study is looking at how a natural sugar called trehalose might help treat heart muscle diseases by mimicking the benefits of fasting, which could protect your heart after events like heart attacks.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11190523

• Understanding how genetic mutations in a heart protein cause cardiomyopathies

  This study is looking at how certain inherited changes in a heart protein can cause heart problems, especially a condition called hypertrophic cardiomyopathy, to help find better treatments for people with this condition.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11145240

• Understanding how increased calcium uptake in mitochondria affects heart function in children with mitochondrial diseases

  This study is looking at how calcium in tiny parts of cells called mitochondria affects heart energy in kids with mitochondrial cardiomyopathies, hoping to find new ways to help their hearts work better.

  NIH research University of Utah · Salt Lake City, United States · NIH-11077867

• Understanding genetic heart muscle diseases

  This study is looking at how changes in your genes can affect heart muscle function in people with conditions like hypertrophic and dilated cardiomyopathy, so we can better understand how to tailor treatments just for you.

  NIH research University of Washington · Seattle, United States · NIH-11066524

• Investigating the role of cardiac troponin I in heart muscle diseases

  This study is looking at how changes in a protein called cardiac troponin I can lead to heart muscle diseases and aims to find new ways to help patients with these inherited conditions by improving how heart cells produce energy.

  NIH research Stanford University · Stanford, United States · NIH-10985329

• Understanding Heart Muscle Weakness and Thickening

  This research explores how tiny proteins in heart muscle cause conditions like hypertrophic and dilated cardiomyopathy, aiming to find new ways to help patients.

  NIH research University of Arizona · Tucson, United States · NIH-10983349

• Developing MRI-compatible tools for diagnosing and treating heart diseases

  This study is working on better ways to take pictures of the heart using MRI, so doctors can more easily diagnose and treat heart problems, especially in kids and adults with certain heart diseases, without needing to do more invasive procedures.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10918188

• Investigating heart muscle diseases and targeted treatments

  This study is looking at how changes in certain proteins affect how well the heart muscle works in people with heart conditions like hypertrophic and dilated cardiomyopathy, with the goal of finding new ways to help improve heart function.

  NIH research University of Washington · Seattle, United States · NIH-10864724

Related topics

Quick answers

How many Cardiomyopathies clinical trials are recruiting right now?

39, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (11 trials), Italy (7 trials), United Kingdom (5 trials), Netherlands (4 trials), China (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →