Using simvastatin to protect the heart during cardiac surgery
A Study of Simvastatin on Myocardial Protection and Cardiac Function Undergoing Cardiac Surgery With Cardiopulmonary Bypass
This study tests if simvastatin can help protect the heart and improve recovery for patients having cardiac surgery for heart defects or valve problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 369 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT01653223 on ClinicalTrials.gov |
What this trial studies
This study investigates the myocardial protection effects of simvastatin in patients undergoing cardiac surgery for congenital heart disease and isolated heart valve disease. The research aims to determine whether simvastatin can reduce myocardial injury and improve cardiac function during and after surgery, particularly in cases involving cardiopulmonary bypass. Conducted at two medical centers, this interventional study will assess the long-term benefits of simvastatin postoperatively.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 with congenital heart disease or isolated heart valve disease.
Not a fit: Patients with coronary artery disease or those allergic to statins will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved heart function and reduced complications for patients undergoing cardiac surgery.
How similar studies have performed: Previous studies have indicated that statins may provide myocardial protection, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * More than 18-year-old, * Congenital heart disease(not complex), * Isolated heart valve disease, Exclusion Criteria: * Coronary artery disease * Allergy for statins * Poor liver function,Hepatitis * Gestation women and Breast-feeding women
Where this trial is running
Guangzhou, Guangdong
- The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Jing-song Ou, MD,PhD — The Frist Affiliated Hospital, Sun Yat-sen University
- Study coordinator: Jing-song Ou, MD, PhD
- Email: oujs2000@yahoo.com
- Phone: 8620-87755766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.