Newborn brain injury risk during birth transition in babies with congenital heart defects
Official title: The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD study
Funded at University of California, San Francisco · NIH-11474556 · Data updated 2026-11-12
This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $125,882 |
| NIH project number | 3R01NS125404-05S1 |
| Project ID | NIH-11474556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people carrying a fetus diagnosed with transposition of the great arteries (TGA) and newborns with TGA before cardiac surgery who can receive care at UCSF or the collaborating site are ideal candidates.
✕Less likely to help
People without congenital heart disease or babies who already had corrective heart surgery or are far beyond the newborn period are unlikely to benefit directly from this project.
What this research studies
If your baby has transposition of the great arteries (TGA), this project follows pregnancies and newborns through the perinatal transition to study brain health. Researchers will use fetal and newborn MRI, bedside brain monitoring, and measures of heart and blood flow around the time of birth to look for signs of delayed brain development and white matter injury. They will compare physiologic changes during the first hours and days of life and look for prenatal biomarkers that predict later injury. The goal is to identify timing and targets for simple protective steps around delivery, such as delayed cord clamping.
Why it matters
Potential benefit: If successful, this work could help identify babies at highest risk and guide perinatal care changes to reduce newborn brain injury and improve long-term development.
How similar studies have gone: Delayed cord clamping and neonatal brain monitoring have shown neuroprotective or diagnostic value in other newborn populations, but applying these approaches specifically to TGA during perinatal transition is relatively new.
Where this research is happening
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University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Peyvandi, Shabnam — University of California, San Francisco
- Study coordinator: Peyvandi, Shabnam
Related research
Other NIH-funded projects on the same topics.
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Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
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Protecting newborn brains in babies born with transposition of the great arteries
Doctors will follow babies with transposition of the great arteries from pregnancy through birth to find early signs and ways to protect their brains during the newborn transition.
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Brain injury risks in preterm newborns with congenital heart disease
This grant studies how being born preterm with congenital heart disease affects brain development and injury, to help improve outcomes for affected babies.
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Investigating brain injury in preterm newborns with congenital heart disease
This study is looking at how different heart surgeries for newborns with congenital heart disease might affect their brain development and risk of injury, especially for those born early, and it also checks if genetics play a role in their outcomes, all to help these little ones have better futures.
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Investigating brain injury risks in newborns with congenital heart disease.
This study is looking at how changes in blood flow and heart function when babies are born can impact brain health in newborns with a heart condition called transposition of the great arteries, and it aims to find ways to protect their brains and improve their care.
-
Multimodal AI to improve genetic diagnosis of congenital heart disease
A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.