Newborn brain injury risk during birth transition in babies with congenital heart defects
The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD study
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11474556
This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11474556 on ClinicalTrials.gov |
What this research studies
If your baby has transposition of the great arteries (TGA), this project follows pregnancies and newborns through the perinatal transition to study brain health. Researchers will use fetal and newborn MRI, bedside brain monitoring, and measures of heart and blood flow around the time of birth to look for signs of delayed brain development and white matter injury. They will compare physiologic changes during the first hours and days of life and look for prenatal biomarkers that predict later injury. The goal is to identify timing and targets for simple protective steps around delivery, such as delayed cord clamping.
Who could benefit from this research
Good fit: Pregnant people carrying a fetus diagnosed with transposition of the great arteries (TGA) and newborns with TGA before cardiac surgery who can receive care at UCSF or the collaborating site are ideal candidates.
Not a fit: People without congenital heart disease or babies who already had corrective heart surgery or are far beyond the newborn period are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help identify babies at highest risk and guide perinatal care changes to reduce newborn brain injury and improve long-term development.
How similar studies have performed: Delayed cord clamping and neonatal brain monitoring have shown neuroprotective or diagnostic value in other newborn populations, but applying these approaches specifically to TGA during perinatal transition is relatively new.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEYVANDI, SHABNAM — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: PEYVANDI, SHABNAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury