Condition

Ischemic Heart Disease clinical trials and research

• 47Clinical trials
• 12NIH research projects
• 1New in 30 days
• 20Countries

Newest Ischemic Heart Disease clinical trials

All recruiting trials (47)

• Outpatient Cardiac Telerehabilitation for Ischemic Heart Disease

  This study tests whether an outpatient cardiac telerehabilitation program can be as safe and effective as conventional rehab for people with ischemic heart disease.

  Recruiting Lithuanian University of Health Sciences · Kulautuva · NCT07927829

• See if stopping long-term aspirin is as good as continuing it in older adults with stable ischemic heart disease

  In adults 65 and older with stable ischemic heart disease, this trial tests whether stopping daily low-dose aspirin is not worse than continuing it.

  Recruiting at 2 sites Phase 4 Odense University Hospital · Copenhagen and 1 other locations · NCT07795398

• QFR-guided virtual stenting to optimize PCI before the procedure

  We’re testing whether using QFR-based virtual stenting before PCI can improve heart-procedure outcomes compared with standard angiography planning in adults with coronary artery disease.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07635407

• LONG NAGOMI PMCF: follow-up of the Ultimaster Nagomi stent in long coronary artery lesions

  This project tests the Ultimaster Nagomi drug-eluting stent in adults undergoing PCI for long coronary lesions to collect real-world safety and effectiveness data.

  Recruiting at 10 sites Fundación EPIC · Cabueñes and 9 other locations · NCT07399002

• Endocardial delivery of stem-cell derived heart cells to help severe heart failure

  This study tests endocardial delivery of HS-001 cell sheets made from iPSC-derived cardiomyocytes in adults with severe heart failure and reduced ejection fraction to see if it is safe and may improve heart function over 26 weeks.

  Recruiting at 5 sites Phase 1/2 Heartseed Inc. · Tsukuba, Ibaraki and 4 other locations · NCT07347197

• Deep learning to analyze and track echocardiograms

  This project will test AI tools that help clinicians read echocardiograms and flag adults who may have genetic cardiomyopathy, ischemic heart disease, or cardiac amyloidosis to see if interpretation improves and diagnoses happen faster.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07308704

• ADR-002K after CABG for heart failure due to ischemic heart disease

  A phase II trial tests ADR-002K, a patient’s own fat-derived stem cells, added to the heart surface during CABG to see if it improves outcomes in people with ischemic heart failure.

  Recruiting Phase 2 Rohto Pharmaceutical Co., Ltd. · Osaka, Suita · NCT07192211

• Cardiovascular risk in people with Crohn's disease and ulcerative colitis

  This study tests whether people with inflammatory bowel disease have different heart-attack or stroke risk over two years compared with matched controls.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT07095634

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

  This study tests advanced, non-contrast and extended clinical cardiac MRI techniques to see how heart tissue features differ between people with heart disease and healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07081711

• Coronary CT angiography versus standard follow-up after stent placement for high-risk patients

  This trial will test whether using coronary CT angiography instead of usual follow-up care helps people at high risk after stent placement stay healthier.

  Recruiting at 2 sites Samsung Medical Center · Bucheon-si and 21 other locations · NCT07009418

• Assessing arterial stiffness and heart disease risk using a novel technology

  This study is testing a new, no-touch technology to measure how stiff your arteries are and see if it can help figure out your risk for heart disease.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06984211

• Carbohydrate loading for diabetic patients undergoing heart surgery

  This study is testing if eating carbohydrates before heart surgery can help people with type 2 diabetes recover better and have fewer complications.

  Recruiting Damascus University · Damascus · NCT06951308

• Understanding brain and heart injuries after bleeding in the brain

  This study looks at how bleeding in the brain affects both the brain and the heart in adults to better understand the connection between these injuries.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06906432

• Pulsed field ablation versus radiofrequency for ventricular tachycardia after a heart attack

  This trial will test whether pulsed field ablation (FARAPOINT) can treat ventricular tachycardia after a heart attack more efficiently and with similar safety compared with standard radiofrequency ablation in people with ischemic cardiomyopathy.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06891456

• Ultrathin strut stent for patients on blood thinners

  This study is testing a new type of stent for patients on blood thinners to see if it can safely reduce the time they need to take additional blood-thinning medication after heart procedures.

  Recruiting at 13 sites Fundación EPIC · Albacete and 12 other locations · NCT06863155

• Evaluating heart muscle viability in patients with ischemic heart disease using advanced imaging techniques

  This study is testing a new imaging method to see if it can better identify healthy heart muscle in patients with ischemic heart disease compared to the traditional imaging techniques before they have heart surgery.

  Recruiting Shanghai East Hospital · Shanghai, Shanghai Municipality · NCT06712862

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• New cardiac rehabilitation treatment for ischemic heart disease

  This study is testing a new heart rehab program that combines breathing exercises, exercise therapy, and shock wave treatment to see if it helps people with ischemic heart disease more than the usual rehab methods.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT06681506

• Essential Pro paclitaxel‑eluting coronary balloon post-market follow-up (rEPIC04E-HK)

  This project will follow people with coronary artery disease treated with the Essential Pro paclitaxel‑eluting coronary balloon to see if the device is safe and works well in routine care.

  Recruiting Fundación EPIC · Lai Chi Kok · NCT06631157

• Investigating different doses of adenosine for heart imaging

  This study tests whether different doses of adenosine can improve heart imaging for people suspected of having chronic coronary syndrome.

  Recruiting Phase 4 Region Skane · Lund · NCT06578234

• Comparing enteric-coated and plain aspirin to reduce heart disease risks from air pollution

  This study is testing whether enteric-coated or plain low-dose aspirin can better help people with heart disease reduce their risks from air pollution, along with providing tips to stay healthy.

  Recruiting Rajaie Cardiovascular Medical and Research Center · Tehran, Tehran Province · NCT06541691

• Using lung ultrasound to improve outcomes in cardiac surgery patients

  This study is testing if using lung ultrasound can help doctors find lung problems earlier in patients after heart surgery compared to regular X-rays and CT scans.

  Recruiting Saint Petersburg State University, Russia · Saint Petersburg, Sankt-Peterburg · NCT06377449

• Comparing radiofrequency ablation to implantable defibrillator for ventricular tachycardia in heart disease patients

  This study is testing whether a procedure called radiofrequency ablation is better than an implantable defibrillator for helping heart disease patients with a specific type of fast heartbeat feel better and live longer.

  Recruiting University Hospital, Toulouse · Toulouse, France · NCT06294028

• Using umbilical cord cells to treat ischemic heart disease

  This study is testing if giving umbilical cord cells to people with heart disease can help improve their heart function.

  Recruiting at 3 sites Phase 2 University of Louisville · Miami, Florida and 2 other locations · NCT06145035

• Comparing two methods for diagnosing heart conditions in patients with non-ST elevation acute coronary syndrome

  This study is testing if a non-invasive heart scan can safely and effectively diagnose heart conditions in patients with certain types of heart attacks, compared to the traditional invasive method.

  Recruiting at 6 sites Copenhagen University Hospital, Rigshospitalet · Copenhagen, Hellerup and 5 other locations · NCT06101862

• Hyperpolarized MRSI in Ischemic Heart Disease: A Metabolic Investigation of the Heart Muscle

  This study is testing a new imaging technique to see how heart muscle metabolism is affected in people with ischemic heart disease.

  Recruiting Aarhus University Hospital · Aarhus, Central Jutland · NCT06054516

• Using a new tool to support decisions for patients with ischemic heart disease

  This study tests whether a new software tool can help doctors make better treatment decisions for patients with ischemic heart disease and improve their chances of staying out of the hospital.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen Ø · NCT06033014

• Comparing two strategies for treating coronary bifurcation lesions

  This study is testing whether using one stent with a special balloon is just as good as using two stents for treating certain heart blockages in patients.

  Recruiting Saint Vincent's Hospital, Korea · Suwon, Gyeonggi-do · NCT06002932

• Comparing body temperature management during heart surgery

  This study is testing whether managing body temperature differently during heart surgery can lead to better outcomes for patients.

  Recruiting at 8 sites University of Leicester · Leicester, Leicestershire and 10 other locations · NCT05996120

• Registry of brain-heart comorbidity in China

  This study is trying to build a big database to better understand and manage the connection between brain and heart problems in people across China.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality and 13 other locations · NCT05961748

• Using GeriKit to assess older adults with heart disease

  This study is testing a mobile app called GeriKit to see if it can help doctors better understand and assess older adults with heart disease.

  Recruiting NYU Langone Health · New York, New York · NCT05788666

• Post-market follow-up of Coroflex® ISAR NEO coronary stent system

  This study is testing how safe and effective the Coroflex® ISAR NEO stent is for patients who need it in real-life situations.

  Recruiting at 26 sites Fundación EPIC · Aix-en-Provence and 25 other locations · NCT05698732

• Using a dynamic roadmap system to guide heart artery pressure measurements

  This study is testing a new system that uses advanced software to help doctors measure heart artery pressure more accurately during procedures for patients with chest pain or heart issues.

  Recruiting Yonsei University · Yongin, Gyeonggi-do · NCT05682118

• Evaluating coronary blood flow and resistance in patients with angina

  This study is testing if using a special medication during heart tests can help people with angina understand their heart's blood flow and resistance better, while also checking how well these tests predict future heart problems.

  Recruiting National Taiwan University Hospital Hsin-Chu Branch · Hsinchu · NCT05672706

• Development of advanced MRI techniques for heart disease assessment

  This study is testing new MRI techniques to see how heart tissue differs between people with heart disease and healthy individuals to improve heart assessments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05654272

• Transplanting heart tissue to aid recovery after heart surgery

  This study is testing if using small pieces of heart tissue from patients' own hearts during surgery can help them heal better and improve heart function after dealing with heart disease and heart failure.

  Recruiting Hospital District of Helsinki and Uusimaa · Helsinki, Uusimaa · NCT05632432

• Post-market follow-up for the SUPRAFLEX CRUZ stent in patients with coronary artery disease

  This study is testing how well the SUPRAFLEX CRUZ stent works and if it's safe for people with coronary artery disease who are getting treated in real-life hospital settings.

  Recruiting at 21 sites Fundación EPIC · Elche, Alicante and 20 other locations · NCT05617599

• Evaluation of a new biodegradable polymer coronary stent for heart disease

  This study is testing a new type of heart stent made from biodegradable material to see if it works better and is safer for people with coronary artery disease compared to a traditional stent.

  Recruiting Samsung Medical Center · Seoul · NCT05444452

• Assessing heart disease risk using carotid ultrasound and stress tests

  This study is testing if combining a special ultrasound of the neck with stress tests can better identify people at risk for serious heart problems over the next three years.

  Recruiting at 5 sites Queen's University · Calgary, Alberta and 5 other locations · NCT05416385

• Evaluating nerve damage risk after radial artery procedures

  This study is testing if patients who have procedures on their radial artery for heart disease experience nerve damage by checking their nerve function before and after the procedure.

  Recruiting Aarhus University Hospital Skejby · Aarhus · NCT05365282

• Evaluating aspirin's effectiveness in patients with chronic coronary syndromes who can't undergo revascularization

  This study is testing whether aspirin can help people with chronic coronary syndromes who can't have surgery to improve their heart health.

  Recruiting Phase 4 Kyoto University, Graduate School of Medicine · Kyoto · NCT05347069

• Comparing Clopidogrel and Aspirin after Stent Implantation for Heart Disease

  This study is testing whether clopidogrel or aspirin is better for heart disease patients after they have received a stent to see which one helps them avoid complications in the year following their treatment.

  Recruiting Yonsei University · Seoul · NCT05320926

• Evaluating long-term outcomes in patients with coronary artery disease

  This study is testing new imaging techniques and assessments to see if they can help doctors better understand and treat patients with coronary artery disease.

  Recruiting Chonnam National University Hospital · Gwangju · NCT05124249

• Imaging heart blood flow using a special PET scan

  This study is testing a special PET scan to see how well it can measure blood flow in the hearts of people with known or suspected heart disease.

  Recruiting University of Aarhus · Aarhus, Aarhus N · NCT04451551

• Comparing PCI and medical therapy for chronic total occlusion in heart disease

  This study is testing whether a new heart procedure using special stents can help people with blocked arteries feel better and have fewer heart problems compared to just taking medication.

  Recruiting at 14 sites Aarhus University Hospital Skejby · Aarhus N and 26 other locations · NCT03563417

• Collecting biological samples and imaging data to study heart health and disease

  This study is collecting health information and samples from people with heart conditions and healthy volunteers to learn more about heart health and disease.

  Recruiting National Heart Centre Singapore · Singapore, Singapore · NCT02804269

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cross-talk between bone and blood cells to fight clogged arteries

  A study from Stanford is testing whether renewing aging skeletal stem cells can reset immune cells and slow or stop atherosclerosis.

  NIH research Stanford University · Stanford, United States · NIH-11376063

• Endothelial Fli1 and heart disease in ischemia

  A study in people with heart disease clues how a blood-vessel gene, Fli1, helps protect the heart during a heart attack.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11365606

• Heart lymphatic vessels and recovery after heart attack

  Researchers will grow and activate lymphatic vessels in the heart to help heart muscle survive and recover after a heart attack.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11247939

• Exosome therapy to protect the heart after a heart attack

  Engineered cell-derived exosomes are being developed to carry protective molecules to heart cells after a heart attack to limit damage and improve recovery.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11213940

• Understanding how different body systems affect heart disease

  This project explores if adjusting communication between certain stem cells can help treat heart disease caused by plaque buildup.

  NIH research Stanford University · Stanford, United States · NIH-11175974

• Indoor air filtration to slow atherothrombosis in adults with prior heart disease

  A long-term trial will test whether using affordable indoor air purifiers reduces markers of blood vessel disease in older adults with a history of ischemic heart disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11146420

• Improving heart imaging for women with ischemic heart disease

  This study is looking at new ways to take heart pictures for women with heart problems, especially those who might not have blockages but still have issues that are hard to spot, like many female veterans. The goal is to use a special type of heart MRI that doesn't use gadolinium to help doctors find these hidden heart

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11073070

• Understanding how heart lymphatics help repair damage after heart attacks

  This study is looking at how boosting the growth of lymphatic vessels in the heart after a heart attack can help improve heart function and speed up healing by reducing inflammation, and it's designed for anyone interested in new ways to support heart recovery.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11003752

• Improving heart repair after a heart attack using specialized exosomes

  This study is looking at how special tiny particles called exosomes can help heal the heart after a heart attack by delivering helpful materials to damaged heart cells, and it’s designed for people who have experienced heart damage.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-10951495

• Using a safe MRI method to improve heart disease diagnosis in patients with kidney issues

  This study is testing a new, safer MRI method to help doctors better diagnose heart problems in people with kidney issues, using a special substance that doesn't harm the kidneys, so you can get the care you need without extra risks.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10890627

• Using air filters to slow heart disease progression

  This study is looking at whether using affordable air purifiers at home can help lower harmful air pollution and improve heart health for people with a history of heart disease, including both Hispanic and non-Hispanic adults.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10854852

• Investigating how a protein called Junctophilin-2 is affected in heart disease

  This study is looking at how a protein called Junctophilin-2 (JPH2) is affected in heart disease, specifically how it gets broken down by an enzyme, which might change how heart cells work and lead to heart failure, with the hope that this research will help find new treatments for people with heart problems.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10804645

Related topics

Quick answers

How many Ischemic Heart Disease clinical trials are recruiting right now?

47, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (8 trials), Denmark (7 trials), South Korea (6 trials), China (5 trials), Spain (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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