Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This international registry collects real-world data on the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease (ACHD) patients. It aims to assess prescription patterns, safety, tolerability, and the potential benefits of SGLT2i on heart failure-related outcomes. Given the high morbidity and mortality associated with heart failure in ACHD, this study seeks to provide insights into a novel treatment approach that has shown promise in other heart failure populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Congenital heart defect.
* Age ≥ 18 years.
* Initiated on treatment with an SGLT2i.

Exclusion Criteria:

\- No consent for data collection.

Where it's running

• Johns Hopkins University
  Baltimore, Maryland, United States Recruiting
• Helen DeVos Children's Hospital
  Grand Rapids, Michigan, United States Recruiting
• Mount Sinai Fuster Heart Hospital
  New York, New York, United States Recruiting
• Heart Center Duisburg (Evangelical Hospital Niederrhein)
  Duisburg, Germany Recruiting
• Leiden University Medical Center (LUMC)
  Leiden, South Holland, Netherlands Recruiting
• Amsterdam University Medical Center
  Amsterdam, Netherlands Recruiting

Study contacts

• Principal investigator: Anastasia D. Egorova, MD PhD — Leiden University Medical Center
• Study coordinator: Ralph M.L. Neijenhuis, MD
• Email: r.m.l.neijenhuis@lumc.nl
• Phone: +31 71 5262020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.