Profiling micro RNA in newborns with congenital heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect plasma samples from neonates diagnosed with severe congenital heart disease (CHD) to investigate the molecular mechanisms behind abnormal clotting profiles that may lead to thrombosis. By analyzing extracellular vesicle micro RNA, the study seeks to enhance understanding of the clotting risks these infants face during the perioperative period. The research will focus on a small cohort of ten neonates at Boston Children's Hospital, providing insights into the fetal-maternal regulation of clotting in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All neonates with a diagnosis of severe Congenital Heart Disease undergoing surgery at Boston Children's Hospital in the first week of life

Exclusion Criteria:

* None

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Rachel Bernier, MPH
• Email: rachel.bernier@childrens.harvard.edu
• Phone: 857-218-5348

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease

  This study is trying to see if a new type of diabetes medication can help adults with congenital heart disease feel better and manage their heart failure symptoms.

  Recruiting at 11 sites Leiden University Medical Center · Baltimore, Maryland and 10 other locations · NCT06932081

• Improving fitness for adolescents with the Fontan circulation

  This study will test whether a home-based digital exercise program helps 10–17-year-olds with the Fontan circulation become more active and improve fitness compared with enhanced usual care.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06918795

• Integrated prenatal and postnatal treatment for newborns with critical congenital heart disease

  This study is testing a new approach that combines care before and after birth for newborns with serious heart defects to see if it can improve their treatment and recovery.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT06768008

• Assessing heart function in children with single-ventricle congenital heart disease

  This study is testing a new 3D heart imaging technique to see if it can better measure heart size and function in children and young adults with a specific type of heart defect compared to the standard MRI method.

  Recruiting Duke University · Durham, North Carolina · NCT05262907

• Long-term safety follow-up after autologous cardiac stem cells in kids with single ventricle heart disease

  This study checks whether autologous cardiac stem cells (JRM-001) remain safe for up to a year in children who already received them after heart reconstructive surgery.

  Recruiting Metcela Inc. · Okayama, Okayama-ken · NCT07884318

• Thromboelastometry to Predict Thrombosis and Survival in Glial Tumor Surgery

  Aimed at people with glial tumors undergoing surgery, the study tests whether thromboelastometry and other blood tests can predict blood-clot risk and survival.

  Recruiting Fundacion Clinic per a la Recerca Biomédica · Barcelona · NCT07813377

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.