Heart development study using patient stem cells to understand NOTCH1 and congenital heart disease

Who could benefit from this research

What this research studies

This project uses human induced pluripotent stem cells from patients and genome editing to create heart cell types and 3-D heart-like structures that reflect how NOTCH1 variants may disrupt development. Researchers will compare ventricular- and atrial-like cells and study how NOTCH1 loss changes cell growth and lineage formation relevant to common birth defects of the heart. The work builds on prior findings and aims to reveal human-specific mechanisms that mouse models cannot fully capture. The findings could point to new ideas for diagnosing or eventually treating congenital heart disease tied to NOTCH1 abnormalities.

Why it matters

Where this research is happening

• Research Inst Nationwide Children's Hosp
  Columbus, United States Active

Researchers

• Principal investigator: Zhao, Mingtao — Research Inst Nationwide Children's Hosp
• Study coordinator: Zhao, Mingtao

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.