Genetic clues to congenital heart defects and outcomes
Official title: Elucidating the contributions of genetic variation to congenital heart disease causality and outcomes
Funded at Icahn School of Medicine at Mount Sinai · NIH-11422502 · Data updated 2026-11-12
This grant studies how genetic differences contribute to congenital heart defects (CHD) and how these variations affect health over time, with patient data from a large biobank and health records.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 20, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $3,095,910 |
| NIH project number | 1P01HL187164-01 |
| Project ID | NIH-11422502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with congenital heart defects or a genetic basis for CHD, and families contributing sequencing data and health records.
✕Less likely to help
Individuals without CHD or relevant genetic data may not directly benefit.
What this research studies
This project uses existing genetic data and new sequencing approaches to understand what genetic changes cause CHD. It combines genomic information from many patients with clinical records and imaging to map how genes influence CHD risk and outcomes. The work aims to uncover new candidate genes and mechanisms that could inform future diagnostics and therapies for people with CHD. The team collaborates across multiple projects and uses computational and administrative support to integrate findings.
Why it matters
Potential benefit: Findings could lead to better genetic counseling, earlier diagnosis, and personalized management for patients with CHD.
How similar studies have gone: Previous CHD genetics studies have identified key genes, but half of CHD causality remains unexplained, making this work both building on and expanding prior findings.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Gelb, Bruce D — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gelb, Bruce D
Related research
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Multimodal AI to improve genetic diagnosis of congenital heart disease
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-
Multimodal AI to improve genetic diagnosis of congenital heart disease
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.