Cognitive Remediation Therapy for improving cognitive and emotional skills in schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of Cognitive Remediation Therapy (CRT) on cognitive and emotional functioning in individuals with schizophrenia. It involves a randomized controlled design with 60 participants, including 30 diagnosed with schizophrenia and 30 healthy controls. Participants with schizophrenia will receive CRT over 12 weeks, focusing on enhancing attention, memory, and emotional regulation through structured exercises. The study will utilize EEG and GSR measurements to assess changes in brain activity and emotional responses before and after the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria (Schizophrenia Group):

* Diagnosed with schizophrenia according to DSM-5 criteria
* Age between 18 and 55 years
* Clinically stable (no hospitalization or medication change within 1 month)
* Minimum primary school education
* Able to provide informed consent
* Right-handed (for EEG protocol consistency)

Inclusion Criteria (Healthy Control Group):

* No history of psychiatric or neurological disorders
* Age- and gender-matched to schizophrenia group
* No current medication affecting CNS
* Able to provide informed consent
* Right-handed

Exclusion Criteria (Both Groups):

* Current or past substance use disorder (within the past year)
* Comorbid neurological illness (e.g., epilepsy, traumatic brain injury)
* Current use of benzodiazepines or medications that significantly affect cognitive function
* Intellectual disability or MoCA score \< 20
* Visual or hearing impairments that could interfere with task performance
* Participation in a psychological intervention in the last 3 months

Where it's running

• Beykoz University
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Metin Çınaroğlu, Phd — Istanbul Nisantasi University
• Study coordinator: Eda Yılmazer, Phd
• Email: edayilmazer@beykoz.edu.tr
• Phone: 00905322575880

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• New flutemetamol F18 formulation to see if it works as well as current for brain amyloid imaging

  Researchers are testing a new flutemetamol F18 formulation (GE-287) to see if it identifies brain amyloid as accurately as the current formulation in people 50 and older who are undergoing amyloid PET scans for cognitive decline.

  Recruiting at 5 sites Phase 2 GE Healthcare · Aventura, Florida and 5 other locations · NCT07873463

• Longevity Metrics AI/ML Development Study

  Researchers are testing AI models that score health screening tests and predict outcomes like life expectancy for adults, using ongoing follow-up data.

  Recruiting Longevity Metrics, Inc. · Boulder, Colorado · NCT07808619

• Immersive nature-based wellbeing program for older adults with cognitive impairment

  A nature-inspired immersive virtual reality program is being tested to see if it can improve well-being and daily function for older adults with mild to moderate cognitive impairment.

  Recruiting Consorci Sanitari de Terrassa · Terrassa, Barcelona · NCT07802392

• Hesperidin for better thinking in overweight older adults

  In adults aged 55–75 who are overweight, taking hesperidin or a placebo for 10 weeks will show whether the citrus flavonoid can improve thinking skills like memory, attention, and problem-solving.

  Recruiting University of Glasgow · Shanghai, Shanghai Municipality · NCT07750223

• Structured Receptive Music to Help with Care During Bathing for People with Dementia

  A structured daily music program used during hygiene care is being tested to see if it reduces refusals of care by residents with dementia in French nursing homes.

  Recruiting at 6 sites Lna Sante · Amiens and 11 other locations · NCT07730957

• Risk of delirium and cognitive problems after TUR-P in older adults

  This study tests whether certain perioperative factors can predict delirium and postoperative cognitive dysfunction in people aged 65 and older undergoing transurethral resection.

  Recruiting Muğla Sıtkı Koçman University · Muğla · NCT07719712

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.