Exploring how a specific protein affects thinking problems related to blood vessel issues.
Official title: Investigating the role of Alpha5Beta1 integrin in cognitive dysfunction
Funded at Tulane University of Louisiana · NIH-11040843 · Data updated 2026-11-12
This study is looking at how a specific protein might affect thinking and memory problems in people with vascular dementia and possibly those who have had COVID-19, and it will also explore if combining exercise with a special treatment can help improve brain function for those dealing with these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $119,115 |
| NIH project number | 3RF1AG078677-01A1S1 |
| Project ID | NIH-11040843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive decline, particularly those with vascular dementia or a history of COVID-19.
✕Less likely to help
Patients with cognitive dysfunction not related to vascular issues or COVID-19 may not benefit from this research.
What this research studies
This research investigates the role of the α5β1 integrin protein in cognitive dysfunction, particularly in conditions like vascular dementia (VaD) and its potential link to COVID-19. The study will utilize a mouse model to examine how the expression of this protein changes with age and how it may contribute to cognitive decline. Additionally, the research will explore whether combining exercise with a specific treatment can enhance cognitive function in individuals affected by these conditions. Patients may benefit from insights into how exercise and targeted therapies can improve cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve cognitive function in patients with vascular dementia and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of integrins in cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Bix, Gregory Jaye — Tulane University of Louisiana
- Study coordinator: Bix, Gregory Jaye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.