Subjective thinking challenges in adults with lupus as they age
Official title: Subjective Cognitive Dysfunction in Adults with Systemic Lupus Erythematosus Across the Lifespan
Funded at Hospital for Special Surgery · NIH-11442899 · Data updated 2026-11-12
This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project start | September 15, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $179,000 |
| NIH project number | 1R03TR005820-01A1 |
| Project ID | NIH-11442899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with systemic lupus erythematosus, including those aged 65 and older, who can participate in interviews and mobile assessments.
✕Less likely to help
Meni may not experience immediate benefits; some may not resonate with the interview topics or prefer other research types.
What this research studies
If funded, researchers will talk with adults living with lupus to hear how cognitive problems affect daily life and quality of life. They will use in-depth interviews to capture personal experiences and factors that worsen or improve those cognitive challenges. The study will also pilot a real-time diary method to see how subjective cognitive symptoms change from day to day. Findings could guide patient-centered support and future work on managing cognitive symptoms in lupus across the lifespan.
Why it matters
Potential benefit: If successful, patients with lupus may gain better understanding and tools to manage cognitive symptoms in daily life.
How similar studies have gone: Previous qualitative work suggests subjective cognitive symptoms are important to patients but real-time tracking in lupus is a newer approach.
Where this research is happening
-
Hospital for Special Surgery
New York, United States Active
Researchers
- Principal investigator: Lieber, Sarah Beth — Hospital for Special Surgery
- Study coordinator: Lieber, Sarah Beth
Related research
Other NIH-funded projects on the same topics.
-
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-
Brain immune cells and cognitive trouble in lupus
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Brain causes of thinking and mood problems in childhood lupus
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Understanding cognitive issues in children with lupus
This study is looking at how childhood-onset systemic lupus erythematosus (cSLE) affects kids' thinking and learning, using special brain imaging tools to understand what’s happening in their brains, so we can find better ways to help them.
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Exploring how brain immune cells affect thinking problems in lupus patients
This study is looking at how certain immune cells in the brain might affect thinking and memory problems in people with lupus, and it aims to find out if understanding these cells can help improve cognitive function for patients.
-
Immunostimulatory short non-coding RNAs and lupus
A study in people with lupus looks at tiny RNA pieces that may spark inflammation, to understand if they drive disease activity.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.