Investigating the link between pain sensitivity and cognitive issues in fibromyalgia patients

Investigation of the Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Patients With Fibromyalgia

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT06948903

This study is trying to see how pain sensitivity affects thinking problems in people with fibromyalgia.

Quick facts

Study typeObservational
Enrollment100 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (other)
Locations1 site (Istanbul, Uskudar)
Trial IDNCT06948903 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore how central sensitization symptoms influence cognitive dysfunction in individuals diagnosed with fibromyalgia. It seeks to determine the extent of this relationship and how cognitive complaints correlate with other clinical parameters, including disease severity. The study employs various assessments such as the Central Sensitization Inventory and the Montreal Cognitive Assessment to gather data on participants. By understanding these connections, the research hopes to shed light on the complexities of fibromyalgia and its impact on cognitive function.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-65 who have been diagnosed with fibromyalgia according to the American College of Rheumatology criteria.

Not a fit: Patients with concurrent systemic inflammatory diseases, central nervous system diseases, or other conditions that may lead to cognitive impairment may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of cognitive dysfunction in fibromyalgia patients.

How similar studies have performed: While studies have explored aspects of central sensitization and cognitive dysfunction, this specific investigation into their relationship in fibromyalgia is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Being diagnosed with fibromyalgia according to American College of Rheumatology 2016 criteria
* Being between 18-65 years old
* Being literate
* Accepting to participate in the study

Exclusion Criteria:

* Concomitant systemic inflammatory disease, central nervous system disease (cortical involvement), active infection and malignancy history
* History of illness that may lead to cognitive impairment
* Being \<18 and \>65 years old
* Being illiterate
* Not accepting to participate in the study

Where this trial is running

Istanbul, Uskudar

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Fibromyalgia, Cognitive Dysfunction, Central Sensitisation

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.