Hesperidin for better thinking in overweight older adults
Official title: A Randomized Controlled Trial of Hesperidin for Improving Cognitive Function in Overweight and Obese Middle-Aged and Older Adults
Run by University of Glasgow · NCT07750223 · Data updated 2026-11-12
In adults aged 55–75 who are overweight, taking hesperidin or a placebo for 10 weeks will show whether the citrus flavonoid can improve thinking skills like memory, attention, and problem-solving.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 55 Years to 75 Years |
| Sex | All |
| Enrollment | 105 (estimated) |
| Sponsor | University of Glasgow Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | March 30, 2027 |
| Study ends | March 30, 2027 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07750223 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 55–75 with BMI ≥24 kg/m² or waist circumference meeting criteria, and no major neurological disease or other disqualifying conditions.
✕Probably not a fit
Individuals with significant neurological disease, current weight-loss drugs or certain medications, or stringent vegetarian or other disqualifying lifestyle factors may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled study will compare two doses of hesperidin (300 mg/day and 600 mg/day) to placebo over 10 weeks in 105 overweight or obese older adults. The primary goal is to test if hesperidin enhances cognitive function, focusing on executive function, memory, and attention, with attention to any dose-response effects. Secondary aims include evaluating changes in gut microbiota and related metabolites to explore potential mechanisms. The study will be conducted at community health centers in Shanghai, with eligibility based on age, BMI or waist circumference, and lack of significant neurological disease.
Why it matters
Potential benefit: If successful, hesperidin could be a dietary strategy to support cognitive health in older adults who are overweight or obese.
How similar studies have gone: Previous research in related citrus flavonoids has shown potential cognitive benefits in some populations, but this specific hesperidin dose-ranging approach in this demographic is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 55-75 years * BMI ≥ 24 kg/m² or waist circumference ≥ 90 cm (men) / ≥ 85 cm (women) * Willing to participate and sign informed consent Exclusion Criteria: * MMSE score \< 20 * History of neurological diseases (Parkinson's, Alzheimer's, stroke, etc.) * Malignant tumors, severe liver/kidney/gastrointestinal diseases * Use of weight-loss drugs or antidepressants (except statins) within recent months * Strict vegetarians, binge eating disorder, heavy alcohol consumption * Participation in other intervention studies * Other conditions judged by investigators as unsuitable
Where it's running
-
Community Health Centers in Shanghai
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Min Hou
- Email: minhou@sjtu.edu.cna
- Phone: 13121858610
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.