Condition

Fatigue clinical trials and research

• 64Clinical trials
• 83NIH research projects
• 1New in 30 days
• 20Countries

Newest Fatigue clinical trials

All recruiting trials (64)

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Micro-choice-based approach to fatigue management

  A small study in Basel will test a new four-day group program using micro-choices to help people with fatigue from multiple causes see if it’s doable, acceptable, and may help daily functioning.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT07726082

• HBS-301 for Narcolepsy: daily wakefulness and sleepiness improvement in adults

  This Phase 3 study tests HBS-301 vs placebo in adults with narcolepsy to see if it helps with daytime sleepiness, cataplexy, sleepiness, and fatigue.

  Recruiting at 29 sites Phase 3 Harmony Biosciences Management, Inc. · Birmingham, Alabama and 52 other locations · NCT07675135

• See if Nuvastatic helps with cancer-related fatigue in colon cancer patients on first-line chemotherapy

  This trial tests whether Nuvastatic can lessen fatigue in adults with colon cancer who are receiving their first round of chemotherapy, compared to placebo.

  Recruiting at 6 sites Phase 3 Natureceuticals Sdn Bhd · Srikakulam, Andhra Pradesh and 5 other locations · NCT07669519

• Balance and gait in multiple sclerosis: linking motion data to function

  Researchers will see if precise motion measurements of balance and walking relate to everyday functional tests in adults with MS.

  Recruiting at 2 sites University of Patras · Ioannina and 1 other locations · NCT07630311

• Relaxation and breathing techniques to help with breathlessness and tiredness in cancer patients in palliative care

  This study tests whether progressive muscle relaxation or deep breathing exercises can reduce dyspnea and fatigue and improve self-care in adults with cancer receiving palliative care.

  Recruiting at 4 sites Ankara University · Ankara, YENIMAHALLE and 3 other locations · NCT07619209

• Photobiomodulation before NMES to see if it reduces fatigue and muscle damage

  This trial tests whether a light-based treatment (photobiomodulation) given before a fatiguing electrical stimulation can lessen fatigue, muscle damage, and discomfort in healthy adults.

  Recruiting Federal University of Rio Grande do Sul · Porto Alegre, Rio Grande do Sul · NCT07602933

• Predictors of fatigue over three months in people with Sjögren's disease

  This project will try to see if measures taken at baseline—like pain sensitivity, mood, sleep, and activity—predict how fatigue changes over three months in adults with Sjögren's disease who attend a rheumatology clinic.

  Recruiting Kahramanmaras Sutcu Imam University · Kahramanmaraş · NCT07544394

• Laser acupuncture for fatigue in adults on hemodialysis

  This trial tests whether low-level laser acupuncture can reduce fatigue and improve quality of life for adults with end-stage kidney disease who are on regular hemodialysis, compared with a sham treatment.

  Recruiting Taipei City Hospital · Taipei · NCT07538310

• Remotely Delivered Pilates for MS: Walking, Balance, Fatigue, Mood and Quality of Life

  A 16-week remote Pilates program will be tested to see if it helps walking, balance, fatigue, pain, mood, thinking, and quality of life for people with multiple sclerosis who can participate from home.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07504120

• Relationship Between Gum Disease and Sleep Quality

  This project will see if periodontitis and saliva inflammation markers (IL-6, IL-10, pentraxin-3) are linked to poorer sleep quality and greater fatigue in adults.

  Recruiting Uskudar University · Istanbul, Istanbul · NCT07421960

• Fatigue and thinking problems after allogeneic stem cell transplant (synapse damage or brain GVHD)

  This project uses PET scans and spinal fluid samples to try to find why people who had an allogeneic stem cell transplant have persistent fatigue and thinking problems.

  Recruiting Karolinska University Hospital · Stockholm · NCT07365696

• What in the brain causes fatigue after COVID-19

  This project will see what's happening in the brains of adults with long COVID who have ongoing fatigue or brain fog to find targets for treatment.

  Recruiting Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Baltimore, Maryland · NCT07278388

• Injectable Niagen®Plus given under the skin or into muscle at two dose levels

  This trial tests whether injectable Niagen®Plus (50 mg or 100 mg), given under the skin or into muscle, is safe and raises blood NAD+ in generally healthy adults who report fatigue.

  Recruiting Phase 1 ChromaDex, Inc. · Miami, Florida · NCT07251608

• Post-stroke fatigue and related clinical factors

  We will try to find how common fatigue is and which health and personal factors are linked to it in adults at least three months after their first stroke.

  Recruiting Ankara University · Ankara · NCT07231172

• Sexual problems in women with relapsing-remitting multiple sclerosis

  See if sexual dysfunction is common in women aged 25-50 with relapsing-remitting MS and whether it's linked to fatigue, mood, bladder symptoms, and cognitive problems.

  Recruiting Ege University · Izmir, Bornova · NCT07193823

• RISE‑YA tele‑exercise to reduce fatigue in young adult brain tumor survivors

  This project will test whether a supervised tele‑exercise program called RISE‑YA helps reduce cancer‑related fatigue in young adults who survived brain tumors.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07186556

• Monitoring daily fatigue in adults with cerebral palsy or acquired brain injury

  This project will try to capture how often and how intense fatigue is for adults with cerebral palsy or acquired brain injury by asking them to report symptoms on their phone multiple times a day.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Glostrup Municipality · NCT07135791

• Exercise plus cognitive behavioural therapy for fatigue in women treated for breast cancer in Singapore

  This program tests whether graded exercise combined with cognitive behavioural therapy can reduce fatigue and help women with breast cancer stay on their treatment plans.

  Recruiting at 4 sites National Cancer Centre, Singapore · Singapore and 3 other locations · NCT07116161

• Virtual groups to reduce sarcoidosis-related fatigue

  This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07073963

• Cystic Fibrosis Wellness Program for Adults with Fatigue

  This pilot randomized trial will try a combined cognitive behavioral therapy and physical activity coaching program to see if it helps adults with cystic fibrosis who have significant fatigue sleep better, move more, and sit less.

  Recruiting Johns Hopkins University · Denver, Colorado and 2 other locations · NCT07071324

• Lifting More Than Weights: a resistance exercise program to reduce fatigue after breast cancer across socioeconomic groups

  This project will try a tailored resistance exercise program to see if it helps reduce fatigue and improve readiness to exercise in Appalachian breast cancer survivors from different socioeconomic backgrounds.

  Recruiting West Virginia University · Morgantown, West Virginia · NCT06960720

• Effects of intermittent fasting on sleep and quality of life

  This study is testing if different schedules of intermittent fasting can improve sleep quality and overall well-being in healthy volunteers.

  Recruiting Université Libre de Bruxelles · Brussels · NCT06959069

• How physical fatigue affects cognitive performance in multitasking

  This study tests how being physically tired affects people's ability to think and perform tasks at the same time.

  Recruiting Riphah International University · Islamabad · NCT06941701

• Physical activity program for cancer survivors in Acres Homes

  This study is testing a special exercise program for cancer survivors in Acres Homes to see if it helps them feel stronger and improve their quality of life.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06907706

• Measuring oxygen levels during intense squat exercises

  This study is testing how intense squat exercises affect oxygen levels and fatigue in active individuals to see how hard they can push themselves.

  Recruiting Bundeswehr University Munich · Munich, Bavaria · NCT06884644

• Fisetin for fatigue in older cancer survivors

  This will see if taking fisetin pills in short dosing periods reduces fatigue in cancer survivors aged 65 and older.

  Recruiting Phase 4 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06819254

• Understanding and treating fatigue in primary care patients

  This study is testing a new online therapy for fatigue to see if it helps people in primary care feel better compared to regular treatment.

  Recruiting Karolinska Institutet · Stockholm, Gustavsberg · NCT06786832

• Using smartphone recordings to assess symptoms of Myasthenia Gravis

  This study is testing if smartphone recordings can help track symptoms like speech problems and fatigue in people with Myasthenia Gravis.

  Recruiting Leiden University Medical Center · Leiden, South Holland and 1 other locations · NCT06743490

• Program to support healthcare managers in promoting employee recovery

  This study tests a program that helps healthcare managers learn how to better support their employees' recovery from burnout and improve their sleep.

  Recruiting at 2 sites Karolinska Institutet · Gothenburg and 1 other locations · NCT06678347

• Understanding cancer-related fatigue in survivors

  This study looks at how cancer-related fatigue affects survivors and how they talk about it with their doctors to help improve communication and support.

  Recruiting at 3 sites Wake Forest University Health Sciences · Charlotte, North Carolina and 2 other locations · NCT06634381

• Using magnetic stimulation to reduce fatigue in multiple sclerosis

  This study is testing if a type of magnetic stimulation can help reduce fatigue in people with Relapsing-Remitting Multiple Sclerosis.

  Recruiting Danish Research Centre for Magnetic Resonance · Hvidovre, Capital Region · NCT06569550

• Comparing eccentric and traditional exercise on fatigue in multiple sclerosis

  This study is testing whether eccentric exercise is better than traditional exercise for reducing fatigue in people with multiple sclerosis.

  Recruiting Hunter College of City University of New York · New York, New York · NCT06505421

• Effects of nutrient timing on cancer-related fatigue

  This study is testing if eating all meals within a 10-hour window can help cancer survivors with blood cancers feel less tired and improve their quality of life.

  Recruiting Phase 2 University of Maryland, Baltimore · Baltimore, Maryland · NCT06482515

• Identifying optimal work/rest cycles for military missions in heat

  This study is testing different work and rest schedules for military missions in hot weather to see which ones help soldiers perform better and stay safe from heat-related issues.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT06475339

• Investigating fatigue and cognitive dysfunction in patients after stem cell transplantation

  This study is trying to see if there are specific signs in the blood and spinal fluid that can help identify fatigue and thinking problems in patients who have had stem cell transplants.

  Recruiting Karolinska Institutet · Stockholm · NCT06363396

• Impact of Increased Physical Activity on Rheumatoid Arthritis Outcomes

  This study is trying to see if increasing physical activity after starting a new RA treatment helps people feel better and how fibromyalgia might change that.

  Recruiting Esbjerg Hospital - University Hospital of Southern Denmark · Esbjerg · NCT06289114

• Using Dyanavel XR to treat fatigue in adults with ADHD

  This study is testing if Dyanavel XR can help adults with ADHD feel less tired over 10 weeks compared to a placebo.

  Recruiting Phase 4 Rochester Center for Behavioral Medicine · Rochester Hills, Michigan · NCT06248229

• Improving physical activity for people with mobility impairments

  This study is testing whether providing exercise videos and health coaching can help people with mobility challenges become more active and stay motivated over 32 weeks.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06207084

• Using Transcranial Pulse Stimulation to treat Post-COVID-19 symptoms

  This study is testing if a new brain stimulation treatment can help people with lingering neurological symptoms after COVID-19, like fatigue and memory issues.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06178952

• Rehabilitation program to reduce fatigue after COVID-19

  This study is testing a new rehabilitation program called COVIDEx to see if it can help people with Long COVID feel less tired compared to standard care.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06156176

• Combining therapy to reduce cancer-related fatigue in metastatic cancer patients

  This study is testing if combining therapy with a placebo can help reduce fatigue in people with metastatic cancer.

  Recruiting Phase 2/3 M.D. Anderson Cancer Center · Houston, Texas · NCT06085716

• Dietary intervention to reduce symptoms of long COVID

  This study is testing if a special diet can help adults aged 50 and older with long COVID feel less tired and improve their muscle strength.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT05977179

• How the brain contributes to mental and physical fatigue

  This trial tests whether two drugs that change brain chemicals—methylphenidate and reboxetine—alter how healthy, physically active adults feel and perform during mental and physical fatigue.

  Recruiting Phase 3 Vrije Universiteit Brussel · Brussels, Brussels Capital · NCT05880342

• Using brain stimulation to reduce fatigue after a stroke

  This study is testing whether a brain stimulation treatment can help reduce fatigue in people who have had a stroke.

  Recruiting Phase 2 Weill Medical College of Cornell University · New York, New York · NCT05816603

• Ear acupuncture for patients with multiple myeloma

  This study tests whether ear acupuncture can help improve the quality of life for patients with multiple myeloma by reducing symptoms like anxiety, pain, and fatigue.

  Recruiting at 2 sites University Hospital Tuebingen · Stuttgart and 1 other locations · NCT05762250

• Nutrition's impact on fatigue after stroke

  This study is testing if a nutritional supplement can help stroke survivors feel less tired and improve their overall well-being.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT05728229

• Walking exercise to reduce fatigue in older breast cancer survivors

  This study is testing whether two types of walking exercises can help older women who have survived breast cancer feel less tired.

  Recruiting University of Florida · Gainesville, Florida · NCT05684367

• Training therapists to provide evidence-based therapies for cancer patients

  This study is testing whether training therapists to provide personalized therapy can help cancer patients manage their stress and improve their overall well-being during treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05674357

• Evaluating Redsenol-1 Plus for cancer-related fatigue in adults

  This study is testing if a new treatment called Redsenol-1 Plus can help adults with cancer-related fatigue feel better compared to a placebo.

  Recruiting Canada Royal Enoch Phytomedicine Co., Ltd. · London, Ontario · NCT05664009

• Magnetic stimulation treatment for fatigue after stroke

  This study is testing whether a type of magnetic treatment can help stroke survivors feel less tired and improve their overall well-being.

  Recruiting Phase 2 VA Office of Research and Development · Decatur, Georgia and 1 other locations · NCT05584124

• Monitoring fatigue and attention in sleep-deprived medical residents

  This study is testing a new device that helps track fatigue and alertness in medical residents working night shifts to see if it can spot changes in their brain activity when they’re sleep-deprived.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT05531734

• Effects of electrical stimulation on fatigue in healthy individuals

  This study tests if a mild electrical current applied to the neck can help healthy adults feel less tired and improve their muscle performance.

  Recruiting University of Oklahoma · Norman, Oklahoma · NCT05487131

• Exploring the link between immunoglobulin deficiency and fatigue in multiple sclerosis patients

  This study is trying to see if low levels of a certain antibody in people with multiple sclerosis can be a cause of their fatigue and if treating it could help them feel better.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern · NCT05357781

• Modafinil to reduce fatigue and thinking problems in advanced cancer

  This project tests whether modafinil helps people with advanced cancer who have significant fatigue and related thinking problems.

  Recruiting Phase 1/2 Ottawa Hospital Research Institute · Ottawa, Ontario · NCT05333250

• Impact of American Ginseng on Fatigue in Breast or Gynecological Cancer Patients

  This study is testing if a supplement made from American ginseng and vitamin C can help breast or gynecological cancer patients who feel tired after their treatment feel less fatigued.

  Recruiting at 5 sites Centre Francois Baclesse · Amiens and 9 other locations · NCT05241405

• Home exercise program to enhance quality of life for colorectal cancer patients

  This study tests if a 12-week home exercise program using elastic bands can help improve quality of life for people with colorectal cancer.

  Recruiting National Taiwan University Hospital Hsin-Chu Branch · Hsinchu · NCT05224518

• Dynamic lighting to improve sleep and circadian rhythm in frail older adults

  This test will try dynamic, spectrum-changing hospital room lighting to improve sleep and circadian rhythms for people aged 65 and older during their hospital stay.

  Recruiting Region Skane · Malmö · NCT05107947

• Evaluating the effects of exercise therapy on veterans' health

  This study tests whether a specific exercise program can help U.S. veterans with chronic pain, fatigue, and depression feel better physically and mentally.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT05094297

• Using sodium bicarbonate to improve muscle health in chronic kidney disease

  This study is testing if sodium bicarbonate can help improve muscle health and endurance in people with chronic kidney disease.

  Recruiting Phase 2 University of California, Davis · Sacramento, California and 1 other locations · NCT04984226

• Cognitive Function and Fatigue After Brain Abscess

  This study is testing how brain abscesses affect thinking skills and tiredness in people who have had this condition.

  Recruiting University of Oslo · Oslo · NCT04938362

• Using advanced MRI to study brain changes in stroke patients

  This study is testing a new MRI technique to see how stroke and TIA affect brain connections and if this helps explain the fatigue that many patients feel afterward.

  Recruiting at 2 sites Danish Research Centre for Magnetic Resonance · Copenhagen, København NV and 1 other locations · NCT04118790

• Understanding how fatigue affects effort perception in decision-making

  This study is trying to see how feeling tired affects how people judge the effort needed for tasks, especially to help understand motivation in mental health issues.

  Recruiting Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Baltimore, Maryland · NCT04041154

• Fatigue and muscle health in severe axial spondyloarthritis

  This project will test whether reduced muscle strength, mass, and exercise capacity explain severe fatigue in adults with axial spondyloarthritis who are just starting targeted therapy.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT03940911

NIH-funded research (newest 40 of 83)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Telehealth exercise program to help rural breast cancer survivors fight fatigue

  A telehealth exercise program is being tested to reduce cancer-related fatigue in rural breast cancer survivors.

  NIH research University of Montana · Missoula, United States · NIH-11627181

• DESCANSO: A friendly CBT plan to ease depression, sleep problems, and fatigue in Latino cancer patients

  A Spanish-speaking CBT program called DESCANSO is being tested to help Latino cancer patients feel less tired, sleep better, and happier.

  NIH research Ponce School of Medicine · Ponce, United States · NIH-11601026

• Time-restricted eating for fatigue and frailty in people with cancer

  A 12-week study will test whether eating within a daily 10-hour window helps reduce fatigue and slow frailty in people living with advanced cancer.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11449363

• Gut microbiome imbalance linked to brain fog and fatigue after COVID-19

  A study will explore whether shifts in gut bacteria after COVID-19 contribute to brain fog and fatigue and how this relationship could point to new treatments.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11446349

• Human Herpesvirus 6B and ME/CFS: does the virus cause or follow immune problems?

  A study to see if HHV-6B reactivation is a cause or result of immune problems in people with ME/CFS, using long-term follow-up and biosamples from patients and controls.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11403869

• Understanding fatigue in COVID-19 and beyond

  This grant aims to uncover why fatigue happens in people after COVID-19 and in other conditions, using new brain and body measurements to find clearer targets for treatment.

  NIH research University of Florida · Gainesville, United States · NIH-11400399

• Measuring voice tiredness in the lab and everyday life

  This project uses wearable sensors, lab recordings, and machine learning to track how vocal tiredness builds up and recovers in adults who rely on their voice.

  NIH research University of Central Florida · Orlando, United States · NIH-11393450

• Long COVID as a possible subtype of chronic fatigue syndrome

  A study at a major hospital will look at whether Long COVID shares biology with chronic fatigue syndrome and what genetic and immune factors may link them.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11391125

• Time-restricted eating to help fatigue in blood cancer survivors

  A 12-week program tests whether eating within a daytime 10-hour window can reduce fatigue in people who have survived blood cancers.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11382896

• Is Long COVID a subtype of chronic fatigue syndrome?

  This project looks at whether people with Long COVID share the same genetic and immune signs as people with chronic fatigue syndrome by analyzing large collections of patient data.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11381943

• Improving fatigue and symptom tracking for people with indolent non-Hodgkin lymphoma

  A clinician-researcher is building better patient-reported tools to track fatigue and symptoms in adults with indolent non-Hodgkin lymphoma to guide treatment decisions.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11371049

• REVITALIZE: a telehealth program to reduce fatigue interference for adults with advanced ovarian cancer on PARP inhibitors

  A telehealth program called REVITALIZE aims to help adults with advanced ovarian cancer on PARP inhibitors feel less affected by fatigue and maintain better daily functioning.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11370593

• Somatosensory problems in people with multiple sclerosis and how they worsen fatigue and balance

  This project looks at how sensing troubles in the body’s nerves, common in multiple sclerosis, may make fatigue and balance problems worse.

  NIH research Smith College · Northampton, United States · NIH-11360561

• EnergyPoints app helps cancer survivors use acupressure to ease fatigue and sleep problems

  A patient-friendly app called EnergyPoints guides adults who have cancer or completed treatment to use acupressure at home to feel less fatigued and sleep better.

  NIH research 5 Point App · New York, United States · NIH-11332724

• Acceptance and Commitment Therapy to Help Fatigue and Caregiver Burden in Advanced GI Cancer

  A patient-facing trial will test a telephone-based therapy to help people with advanced gastrointestinal cancer manage fatigue and reduce the stress on their family caregivers.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11330492

• Clinically calibrated Fatigue Test to Predict Dental Restorative Materials Performance

  A new test tool uses accelerated wear and biofilm studies to predict how long dental resin fillings will last in people.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11322737

• Measuring Treatment Regimen Fatigue in older adults living with HIV

  A new tool is being developed to measure the tiredness and burden some older adults with HIV feel from their treatment plans.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11318874

• How teens' sleep patterns affect tiredness and daily functioning

  This project looks at how changes in sleep duration and timing relate to tiredness, daytime sleepiness, and everyday functioning in early adolescents, especially in families facing social or neighborhood challenges.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11305209

• Testing new dental materials to predict their performance in patients

  This study is working on a new way to test dental materials to see how well they hold up in real life, which could help make your dental work last longer and reduce the need for future visits to the dentist.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11289572

• Investigating MitoQ to reduce fatigue in people with Multiple Sclerosis

  This study is looking at whether MitoQ, a special antioxidant, can help reduce fatigue in people with Multiple Sclerosis, as many current treatments don’t work well and can have side effects.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11249112

• Why Long COVID makes people feel physically tired

  This project looks at whether people with Long COVID have leakier blood vessels in the brain that make physical effort feel harder.

  NIH research Hugo W. Moser Res Inst Kennedy Krieger · Baltimore, United States · NIH-11241094

• Chemotherapy and your body clock: links to fatigue

  This research looks at whether chemotherapy disrupts the brain’s central body clock and causes fatigue in people treated for breast cancer.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11239823

• Why parts of the brain sometimes 'go offline' and cause mental tiredness

  This work looks at how brief 'switch-offs' in small brain regions can make people feel mentally exhausted after poor sleep or intense learning.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11238078

• Prefrontal brain stimulation to ease post-stroke fatigue and help language and attention in aphasia

  This project uses gentle electrical stimulation to the front of the brain to help people with aphasia after stroke feel less tired and improve attention and language.

  NIH research Syracuse University · Syracuse, United States · NIH-11231739

• Understanding how chemotherapy affects the body's internal clock and causes fatigue

  This study is looking at how chemotherapy affects the body's natural sleep-wake cycles and causes tiredness in cancer patients, using a special mouse model to find ways to help improve energy levels and overall well-being for those going through treatment.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11210738

• Energize-MBC: a web-based fatigue program for women with metastatic breast cancer

  This project will adapt a cognitive behavioral therapy program delivered online to help women with metastatic breast cancer who have tiring side effects from CDK4/6 inhibitor treatment.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11194344

• Daily time-restricted eating to ease fatigue after blood cancers

  This project sees whether limiting eating to a 10-hour daytime window can help people who finished treatment for blood cancers feel less tired.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11187059

• Helping overused tendons heal instead of getting worse

  This project aims to find ways to make tendons damaged by repeated use recover and stay strong rather than continue to break down for people with tendon overuse injuries.

  NIH research Cornell University · Ithaca, United States · NIH-11178718

• Longer overnight fasting and exercise to reduce fatigue in women with hormone receptor–positive advanced breast cancer

  This project will see if longer overnight fasting and regular exercise help women with hormone receptor–positive advanced breast cancer feel less fatigued and improve their quality of life.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11176126

• Telehealth exercise program to reduce fatigue for rural cancer survivors

  A remote exercise program is being offered to help rural cancer survivors who have ongoing cancer-related fatigue.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11171461

• HHV-6B (a common herpesvirus) and its link to ME/CFS and Long COVID

  This project will follow adults with ME/CFS, some with Long COVID, and healthy controls over time to find out whether reactivation of herpesvirus HHV-6B is linked to changes in symptoms and immune responses.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11159442

• Long COVID may be a form of chronic fatigue syndrome

  This project looks for shared genetic and immune causes in people with Long COVID and people with chronic fatigue syndrome to explain lingering symptoms.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11143218

• Understanding and Predicting Severe Fatigue in Cancer Patients

  This research aims to understand why some cancer patients experience severe fatigue during and after treatment, and to develop ways to predict who might be most affected.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11136232

• What causes fatigue in long COVID and in healthy people

  This project looks at how the brain and muscles create different kinds of fatigue in people with long COVID and in people without COVID.

  NIH research University of Florida · Gainesville, United States · NIH-11134652

• Helping advanced gastrointestinal cancer patients and their caregivers manage fatigue and stress

  This study is looking at how a special therapy called Acceptance and Commitment Therapy (ACT) can help people with advanced gastrointestinal cancer feel less tired and improve their overall well-being, while also supporting their family caregivers who may be feeling overwhelmed. The program includes helpful phone calls

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11077263

• REVITALIZE: A telehealth program to help adults with advanced ovarian cancer manage fatigue while on PARP inhibitors

  This program offers a telehealth approach to help adults with advanced ovarian cancer feel less tired and improve their quality of life while taking PARP inhibitor medications.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11077229

• Improving telehealth therapy for fatigue in people with multiple sclerosis

  This study is testing a new online therapy program to help people with multiple sclerosis manage their fatigue, making it easier for them to get support from home.

  NIH research University of Washington · Seattle, United States · NIH-11070344

• Using an app to help cancer survivors manage fatigue and sleep issues with acupressure

  This study is looking at how well the EnergyPoints app can help cancer survivors manage fatigue and sleep issues by using personalized acupressure techniques, so if you're a cancer survivor wanting to feel better, this app might be just what you need!

  NIH research 5 Point App · New York, United States · NIH-11062928

• Using brain stimulation to help reduce fatigue and improve language skills after a stroke

  This study is looking at how a gentle brain stimulation technique can help people who have had a stroke feel less tired and improve their language and attention skills, making it easier for them to recover and enjoy life more.

  NIH research Syracuse University · Syracuse, United States · NIH-11057160

• Investigating how local sleep affects mental fatigue

  This study is looking at how not getting enough sleep and heavy studying can make you feel tired and less sharp mentally, and it aims to find out how certain brain cells are involved in this process, so we can learn how to help improve sleep and reduce mental fatigue for everyone.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11045769

Related topics

Quick answers

How many Fatigue clinical trials are recruiting right now?

64, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (26 trials), Turkey (Türkiye) (5 trials), Sweden (5 trials), Canada (4 trials), Denmark (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 3, Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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