Understanding cognitive problems after traumatic brain injury
Official title: Functional and Structural Correlates of Cognitive Dysfunction following TBI
Funded at Philadelphia VA Medical Center · NIH-11088023 · Data updated 2026-11-12
This study is looking at how brain injuries can affect memory and thinking by using pigs to learn more about these changes, with the hope of finding new ways to help people recover their cognitive abilities after a traumatic brain injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006511-02 |
| Project ID | NIH-11088023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced moderate to severe traumatic brain injury and are suffering from cognitive dysfunction.
✕Less likely to help
Patients with mild traumatic brain injury or those without cognitive symptoms may not benefit from this research.
What this research studies
This research investigates the cognitive dysfunction that often follows traumatic brain injury (TBI) using advanced animal models. By studying large animals, specifically pigs, researchers aim to uncover how different types of brain injuries affect memory and cognition. They will utilize high-density electrophysiology to analyze changes in neuronal coding related to memory and employ advanced imaging techniques to identify structural changes in the brain. The ultimate goal is to develop new treatment strategies that could help restore cognitive function in individuals affected by TBI.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for cognitive dysfunction in patients with traumatic brain injury.
How similar studies have gone: While there has been some research on cognitive dysfunction following TBI, this approach using large animal models and advanced techniques is relatively novel.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Wolf, John Allen — Philadelphia VA Medical Center
- Study coordinator: Wolf, John Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.