Early diagnosis and intervention for cognitive dysfunction in diabetes patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals aged 45 and older with Type 2 diabetes to assess cognitive function and identify early signs of cognitive decline. Participants will undergo a series of neuropsychological tests, laboratory examinations, brain MRI, and olfactory function measurements to gather comprehensive data on their cognitive health. The study aims to address the current limitations in diagnosing and managing cognitive dysfunction in diabetes patients by collecting and analyzing various biological samples. By enhancing understanding and early intervention strategies, the study seeks to improve outcomes for this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥45 years;
* Type 2 diabetes diagnosed according to the American Diabetes Association criteria;
* Willingness and ability to complete systematic neuropsychological tests;
* Understanding of the research procedures and methods, potential benefits and risks of the trial, and sign written informed consent.

Exclusion Criteria:

* Fewer than 6 years of education;
* Left-handedness;
* Dementia;
* Acute metabolic complications such as diabetic ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months;
* History or presence of neurological or psychiatric disorders;
* Presence of hypothyroidism;
* History of malignancy, or severe kidney or liver dysfunction.

Where it's running

• Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Yan Bi, M.D., Ph.D.
• Email: biyan@nju.edu.cn
• Phone: (86) 25-83105313

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.