40 Hz Gamma Auditory Stimulation for Cognitive Decline in Older Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled trial will compare active 40 Hz gamma auditory stimulation to a sham device in adults over 60 with mild cognitive impairment or mild dementia. The study measures cognitive function, EEG activity, sleep quality, and quality of life to see if the auditory stimulus can modulate brain rhythms and cognitive performance. Safety and tolerability are monitored throughout the intervention. The approach aims to address limitations seen with other gamma stimulation methods by using an auditory modality that may be more practical for daily use. The project is led by Chang Gung Memorial Hospital with site coordination at Chang Gung University in Taoyuan, Taiwan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age over 60 years old.
2. MMSE≤ 24
3. CDR scores of 0.5 and 1
4. Voluntary to sign the Informed Consent Form.

Exclusion Criteria:

1. Diagnosis of other psychiatric or neurological disorders
2. Drug or alcohol addictions.
3. Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
4. History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.

Where it's running

• Chang Gung University
  Taoyuan, Guishan, Taiwan Recruiting

Study contacts

• Study coordinator: Chia-Hsiung Cheng, Ph.D.
• Email: ch.cheng@mail.cgu.edu.tw
• Phone: +886-3-211800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.