Investigating how myeloid cells differ in Alzheimer's disease and HIV-related cognitive issues.
Official title: Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction
Funded at Weill Medical Coll of Cornell Univ · NIH-11034783 · Data updated 2026-11-12
This study is looking at how memory and thinking problems from Alzheimer's disease are different from those caused by HIV in older adults, and it hopes to find special markers in immune cells that can help doctors tell them apart better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $63,017 |
| NIH project number | 3R01AG063846-05S1 |
| Project ID | NIH-11034783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 60 years old who are living with HIV and experiencing cognitive difficulties.
✕Less likely to help
Patients under 60 years old or those without cognitive impairments related to HIV or Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the differences between cognitive impairments caused by Alzheimer's disease and those associated with HIV in older adults. By analyzing myeloid cells, which play a crucial role in the immune response, the study aims to identify unique biomarkers that can help differentiate between these two conditions. Using advanced single-cell epigenome-wide profiling techniques, researchers will explore the genetic and epigenetic signatures of these cells in individuals over 60 years old. This approach could lead to improved diagnostic methods for clinicians treating patients with cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for older adults experiencing cognitive impairments.
How similar studies have gone: Previous research has shown promise in using epigenetic profiling to differentiate between various cognitive disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Ndhlovu, Lishomwa C — Weill Medical Coll of Cornell Univ
- Study coordinator: Ndhlovu, Lishomwa C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.