Nutrition-based interventions to prevent cognitive decline

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the feasibility and effectiveness of a 6-month nutrition-based intervention aimed at preventing cognitive decline in adults at higher risk for dementia. Participants will be randomized into intervention and control groups, with the intervention group receiving nutrition education, cognitive training, and clinical consultations. The control group will receive a healthy recipes cookbook and an invitation to cooking workshops after data collection. Assessments will be conducted at baseline, after the intervention, and at a 6-month follow-up to measure various health and cognitive outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged from 55 to 85 years old;
* At least 4 years in the regular school system;
* Higher individual risk for dementia defined as a score ≥6 points on the Cardiovascular Risk Factors, Aging and Dementia Dementia Risk Score (CAIDE).

Exclusion Criteria:

* Montreal Cognitive Assessment (MoCA) score lower than the validated cutoff points defined as 2 standard deviations below the normative reference value for the corresponding age and education in the Portuguese population;
* Having a medical condition limiting the participation in the intervention (e.g., blindness, amputation…);
* Lack of autonomy in daily activities;
* Diagnosis of dementia or major incapacity.

Where it's running

• Instituto de Saúde Pública da Universidade do Porto
  Porto, Portugal, Portugal Recruiting
• Faculty of Nutrition and Food Sciences, University of Porto
  Porto, Portugal Recruiting

Study contacts

• Study coordinator: Daniela de Sousa, Master
• Email: daniela.sousa@ispup.up.pt
• Phone: +351222061820

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

  This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT05886114

• Using a passive home sensor to find digital signs of brain energy changes from nicotinamide riboside

  This project will try a contact-free home sensor to see if it can detect activity, sleep, and breathing changes related to nicotinamide riboside in people with mild cognitive impairment or mild Alzheimer's.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05245903

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

• Non-invasive brain stimulation plus computer-based memory training for mild cognitive impairment

  This trial will test whether a short course of non-invasive brain stimulation combined with one of two computer-based brain-training programs helps people aged 60–85 with mild cognitive impairment improve memory, thinking, mood, and daily function.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07526740

• Cognitive rehabilitation for ME/CFS brain fog

  Researchers are testing two cognitive rehabilitation approaches to see which helps adults with ME/CFS and brain fog better manage thinking and daily tasks.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07523113

• Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)

  This project will test a short questionnaire called LiCCoS to see if it can spot thinking and everyday mental problems in adults with liver cirrhosis.

  Recruiting University of Malaya · Ambāla, Haryana · NCT07418008

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.