Effects of polyphenols on cognitive decline in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential of polyphenols, found in a Mediterranean diet, to prevent or delay cognitive decline in older adults at risk for Alzheimer's disease. Participants aged 50 and older who are overweight or obese and consume a typical Western diet will be given either a polyphenol supplement or a placebo. The study aims to explore how these dietary interventions may influence brain health and gut microbiome interactions, potentially leading to improved cognitive function. By focusing on the role of gut-derived metabolites, the research seeks to uncover new strategies for healthy cognitive aging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 50+ Years of age
* Male or Female
* At enhanced risk of Alzheimer's Disease (defined as family history of AD, 1st degree family member)
* Habitually consume suboptimal diets such as typical Western Diet (i.e., high in animal products, refined carbohydrates and processed food)
* Able to communicate well in English

Exclusion Criteria:

* Vegan or Vegetarian
* Presence of cognitive impairment at the time of recruitment into the study as measured by the Mini Mental Status Exam (MMSE, score 25-30) and Clinical Dementia Rating (CDR, score=0).
* Pre-existing psychosis or psychiatric conditions
* Currently receiving treatment for dementia
* History of alcohol and/or substance abuse/dependence as determined by a positive endorsement on the MINI+/ If the MINI+ is positive for alcohol or drug dependence, or abuse, the participants will be excluded.
* Heavy use of tobacco (greater than 1/2 pack per day)
* History of cerebrovascular events
* Existing allergies to berry fruits
* Use of oral/IV antibiotics in the last 3 months. Use of probiotics in the last 1 month.
* Recent Changes (last 3 months) in the use of psychoactive medications or other medications that interfere with the measured outcomes.
* Frailty, malnutrition, or food allergy/intolerance requiring special diets.
* Body weight at enrollment greater than 400lbs due to weight restrictions on the MRI table.
* Women who are pregnant, lactating, or postpartum for less than 6months.
* Women of childbearing age who are not practicing birth control or are planning to get pregnant during the study.

Unable to safely participate in the MRI (claustrophobia, presence of devices affected by MRI such as pacemakers, neurostimulators, metallic foreign body, etc.)

* Chronic Pain

Where it's running

• University of California, Los Angeles
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Arpana Church, PhD — The Regents of the University of California, Los Angeles
• Study coordinator: Marika Dy, MPH
• Email: ChurchLab@mednet.ucla.edu
• Phone: 2670089

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.