Using a VR app to improve cognitive skills in patients with mild cognitive impairment
Effectiveness of Telerehabilitation Plus Virtual Reality App in Patients With Subjective Cognitive Decline, and Mild Cognitive Impairment
NA · IRCCS Centro Neurolesi Bonino Pulejo · NCT06793735
This study is testing if a virtual reality app can help improve thinking and social skills in people with mild cognitive impairment compared to regular therapy.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 480 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | IRCCS Centro Neurolesi Bonino Pulejo (other) |
| Locations | 1 site (Messina, Italy) |
| Trial ID | NCT06793735 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of a telerehabilitation program that incorporates a virtual reality (VR) app aimed at enhancing cognitive performance and social skills in patients with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI). Participants will undergo initial assessments including neurological exams and neuropsychological tests, followed by a 6-week intervention where one group uses the VR app while another group engages in traditional cognitive rehabilitation. The study will measure changes in cognitive functions, social skills, brain activity, eye movements, and gait patterns to determine the efficacy of the VR approach compared to conventional methods.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40-80 diagnosed with Mild Cognitive Impairment or Subjective Cognitive Decline.
Not a fit: Patients with severe dementia or psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve cognitive and social functioning in patients with early signs of cognitive decline.
How similar studies have performed: While traditional cognitive rehabilitation has shown benefits, the use of VR in telerehabilitation is an emerging approach that has not been extensively tested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects diagnosed with MCI (AD and PD) according to the criteria of the National Institute on Aging-Alzheimer's Association (NIA-AA, Albert et al., 2011) * Subjects diagnosed with SCD according to diagnostic criteria proposed in research settings (Molinuevo et al., 2017) * All enrolled subjects must be aged between 40 and 80 years and have at least 5 years of education Exclusion Criteria: * Presence of psychiatric disorders (major depression, psychosis, anxiety disorders) * Presence of severe dementia * History of cerebral ischemia * Contraindications to brain MRI: pregnant women, pacemakers, non-latest-generation metal joint prostheses, electrodes, neurostimulators, or prostheses that may interfere with magnetic fields, unless there is a written statement of suitability from the specialist who performed the intervention
Where this trial is running
Messina, Italy
- IRCCS Centro Neurolesi Bonino Pulejo — Messina, Italy, Italy (RECRUITING)
Study contacts
- Study coordinator: Maria Grazia Maggio, PhD, PsyD
- Email: mariagrazia.maggio@irccsme.it
- Phone: +39 090 62128250
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cognitive Dysfunction, Subjective Health, Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Telerehabilitation, Virtual Reality, Subjective Cognitive Decline