Understanding cognitive issues in children with lupus
Biobehavioral Basis and Outcomes of Cognitive Dysfunction in Childhood-Systemic Lupus Erythematosus
This study is looking at how childhood-onset systemic lupus erythematosus (cSLE) affects kids' thinking and learning, using special brain imaging tools to understand what’s happening in their brains, so we can find better ways to help them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10987200 on NIH RePORTER |
What this research studies
This research investigates cognitive dysfunction in children with childhood-onset systemic lupus erythematosus (cSLE), a condition that can significantly affect their mental health and daily functioning. The study aims to explore the underlying neurobiological mechanisms of cognitive dysfunction using advanced imaging techniques such as fNIRS, fMRI, and diffusion tensor imaging. By examining brain structures and functions, the research seeks to identify how inflammation and other factors contribute to cognitive challenges in these children. Ultimately, the goal is to improve diagnosis and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with childhood-onset systemic lupus erythematosus who are experiencing cognitive difficulties.
Not a fit: Patients without a diagnosis of childhood-onset systemic lupus erythematosus or those who do not exhibit cognitive dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cognitive dysfunction in children with lupus, improving their quality of life.
How similar studies have performed: Previous research has indicated a link between cognitive dysfunction and neurobiological changes in lupus patients, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Upadhyay, Jaymin a — Boston Children's Hospital
- Study coordinator: Upadhyay, Jaymin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.