Fatigue and thinking problems after allogeneic stem cell transplant (synapse damage or brain GVHD)
Official title: Fatigue Och Kognitiv Dysfunktion Till följd av Synaptopati Eller Graft Versus Host (GVH) Sjukdom i hjärnan.
Run by Karolinska University Hospital · NCT07365696 · Data updated 2026-11-12
This project uses PET scans and spinal fluid samples to try to find why people who had an allogeneic stem cell transplant have persistent fatigue and thinking problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 75 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Karolinska University Hospital Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | November 28, 2023 |
| Main results expected | December 28, 2027 |
| Study ends | December 28, 2028 |
| Registry record updated | January 26, 2026 |
| Trial ID | NCT07365696 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults who received an allogeneic stem cell transplant, report persistent fatigue or cognitive symptoms, and have PET imaging and/or cerebrospinal fluid samples available through Karolinska follow-up.
✕Probably not a fit
People who did not have an allogeneic transplant, who lack PET images or spinal-fluid samples, or who have no fatigue or cognitive complaints are unlikely to benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients who undergo allogeneic stem cell transplantation at Karolinska are followed in the outpatient clinic and offered systematic measurement of fatigue and cognitive impairment using international standards. As part of the program, cerebrospinal fluid samples and advanced PET imaging are collected or reviewed to study immune and structural changes in the brain. The project is observational and includes retrospective PET images where available. Data will be used for combined immunological and radio‑morphological analyses to link symptoms with biological markers.
Why it matters
Potential benefit: If successful, this work could identify imaging or spinal-fluid markers that help diagnose causes of post-transplant fatigue and cognitive dysfunction and guide more targeted care.
How similar studies have gone: Previous PET and cerebrospinal-fluid studies have detected neuroinflammation and synaptic changes in related conditions, but applying these markers specifically to post-transplant GVHD-related cognitive problems is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: PET images available retrospectively
Where it's running
-
Ksenia Boriskina
Stockholm, Sweden Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.