Examining how myeloid cells differ in Alzheimer's disease and HIV-related cognitive issues
Official title: Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction
Funded at Weill Medical Coll of Cornell Univ · NIH-11010072 · Data updated 2026-11-12
This study is looking at how certain brain cells behave differently in people with Alzheimer's disease compared to those with cognitive issues related to HIV, and it's for anyone interested in understanding these conditions better and how they affect the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $99,012 |
| NIH project number | 3R01AG063846-05S2 |
| Project ID | NIH-11010072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults living with HIV who are experiencing cognitive issues, as well as cognitively normal individuals with HIV.
✕Less likely to help
Patients who do not have HIV or Alzheimer's-related cognitive dysfunction may not benefit from this research.
What this research studies
This research investigates the differences in myeloid cell epigenomes between individuals with Alzheimer's disease and those experiencing HIV-associated cognitive dysfunction. By utilizing advanced techniques such as cellular immunophenotyping and MRI, the study aims to identify unique neurobiochemical markers that can distinguish between these two conditions. Participants will undergo assessments to measure specific neurometabolites in the brain, which may help clarify the relationship between these cognitive disorders. The research seeks to enhance our understanding of how these diseases affect the brain at a cellular level.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients suffering from cognitive dysfunction related to Alzheimer's and HIV.
How similar studies have gone: Previous research has shown promise in using epigenomic profiling to differentiate between various cognitive disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Ndhlovu, Lishomwa C — Weill Medical Coll of Cornell Univ
- Study coordinator: Ndhlovu, Lishomwa C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.