How sepsis affects brain function and memory
Vascular mechanisms of sepsis-induced cognitive dysfunction
This study is looking at how surviving sepsis can affect your memory and learning over time, and it aims to find ways to help prevent or treat these issues for people who have gone through sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11042778 on NIH RePORTER |
What this research studies
This research investigates the long-term cognitive impairments that can occur after a person survives sepsis, a severe response to infection. The study focuses on understanding how certain fragments in the blood can damage the brain's hippocampus, which is crucial for memory and learning. By exploring the mechanisms behind this cognitive decline, the researchers aim to identify potential therapies that could prevent or treat these impairments in sepsis survivors. The approach combines expertise in sepsis and brain injury to uncover new insights into this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived sepsis and are experiencing cognitive difficulties.
Not a fit: Patients who have not experienced sepsis or do not have cognitive impairments related to sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that prevent cognitive decline in sepsis survivors.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of cognitive impairment after sepsis, indicating that this area of study has potential for significant advancements.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Herson, Paco S — Ohio State University
- Study coordinator: Herson, Paco S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.