High-intensity exercise program for older adults with HIV to improve vascular and cognitive health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of a 16-week high-intensity interval training (HIIT) program on vascular and cognitive function in adults aged 50 and older living with HIV who have suboptimal cognition. Participants will be randomly assigned to either the HIIT group or a continuous moderate exercise group, with the aim of determining which approach yields greater improvements in health outcomes. The study will also explore barriers to exercise engagement and participants' perceptions of the interventions through qualitative interviews. Data will be collected at baseline and after the intervention to assess changes in vascular function and cognitive performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50 years and older
* Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
* Neurocognitive Impairment (as assessed using the BRACE+
* Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
* Able to speak, read, and write in English
* Willingness to participate in all study procedures

Exclusion Criteria:

* Diagnosis of mitochondrial disease
* Active substance abuse or factors preventing compliance or safety
* Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
* Chronic kidney disease
* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
* Acute myocardial infarction identified by medical history and ECG
* Pulmonary disease requiring the use of supplemental oxygen
* Poorly controlled diabetes
* Neuropsychologically Intact
* Orthopedic problems that limit ability to perform exercise
* Simultaneous participation in another intervention trial

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Raymond Jones, Ph.D. — University of Alabama at Birmingham
• Study coordinator: Raymond Jones, Ph.D.
• Email: raymondjones@uabmc.edu
• Phone: 205-996-3569

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.