High-intensity exercise program for older adults with HIV to improve vascular and cognitive health
A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults With HIV
This study tests whether a 16-week high-intensity exercise program can help older adults with HIV improve their heart and brain health compared to a moderate exercise routine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT05965518 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of a 16-week high-intensity interval training (HIIT) program on vascular and cognitive function in adults aged 50 and older living with HIV who have suboptimal cognition. Participants will be randomly assigned to either the HIIT group or a continuous moderate exercise group, with the aim of determining which approach yields greater improvements in health outcomes. The study will also explore barriers to exercise engagement and participants' perceptions of the interventions through qualitative interviews. Data will be collected at baseline and after the intervention to assess changes in vascular function and cognitive performance.
Who should consider this trial
Good fit: Ideal candidates are adults aged 50 and older with HIV who are sedentary and experiencing cognitive impairments.
Not a fit: Patients with uncontrolled hypertension, severe cardiac disease, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved vascular and cognitive health for older adults living with HIV.
How similar studies have performed: While there is ongoing research in exercise interventions for HIV patients, this specific approach using HIIT in older adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 50 years and older * Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire * Neurocognitive Impairment (as assessed using the BRACE+ * Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity * Able to speak, read, and write in English * Willingness to participate in all study procedures Exclusion Criteria: * Diagnosis of mitochondrial disease * Active substance abuse or factors preventing compliance or safety * Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG * Chronic kidney disease * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina * Acute myocardial infarction identified by medical history and ECG * Pulmonary disease requiring the use of supplemental oxygen * Poorly controlled diabetes * Neuropsychologically Intact * Orthopedic problems that limit ability to perform exercise * Simultaneous participation in another intervention trial
Where this trial is running
Birmingham, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Principal investigator: Raymond Jones, Ph.D. — University of Alabama at Birmingham
- Study coordinator: Raymond Jones, Ph.D.
- Email: raymondjones@uabmc.edu
- Phone: 205-996-3569
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.