Exploring brain blood flow and function in stroke, depression, dementia, and delirium

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the feasibility of using advanced imaging techniques, such as Transcranial Doppler Ultrasonography and Near Infrared Spectroscopy, to evaluate changes in brain blood flow and neurovascular function in various populations, including healthy individuals and those with cognitive dysfunction, stroke, depression, and delirium. Participants will undergo assessments in a controlled environment, with specific adaptations for those with delirium to minimize environmental changes. The study will also explore optimal stimuli for neurovascular coupling and gather data to inform future research designs.

Why it matters

Who can join: the full rules

* Inclusion Criteria:
* Healthy adults aged over 65 years, free from medical comorbidities or medications that can adversely affect cognitive function or cerebral haemodynamics;
* Stable, well controlled comorbidities (e.g. hypertension);
* A diagnosis of dementia (major neurocognitive disorder), depression, or delirium, according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) criteria;
* Participants on or off anti-dementia drug therapy (acetylcholinesterase inhibitors, NMDA receptor antagonists), and antidepressants;
* A diagnosis of ischaemic (IS) or haemorrhagic (ICH) stroke according to clinical and/or radiological findings, within 72 hours of symptom onset
* Exclusion Criteria:
* Poorly controlled medical comorbidities affecting cerebral haemodynamics or cognitive function (e.g., heart failure, hypertension, type two diabetes);
* Clinically unstable or too unwell to cooperate with the study protocol;
* Lacks capacity or personal consultee to consent to the study.

Where it's running

• University Hospitals of Leicester NHS Trust
  Leicester, Leicestershire, United Kingdom Recruiting
• Leicestershire Partnership Trust
  Leicester, Leicestershire, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: Dr Jatinder Minhas — Clinical Associate Professor of Stroke Medicine
• Study coordinator: James Ball
• Email: jdb58@le.ac.uk
• Phone: 07551300119

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.