Observing brain blood vessel health in a community

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the prevalence and characteristics of cerebral small vessel dysfunction in a community population in Beijing, China, using advanced vascular imaging techniques. It will investigate how vascular risk factors, such as hypertension and diabetes, affect cerebral small vessel dysfunction and its relationship with cognitive and cerebrovascular health. The study will involve community-dwelling adults aged 50-75 years and will not include any interventions, focusing instead on observational data collection. The findings could provide insights into the early pathologic changes associated with major brain diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Community-dwelling adults aged 50-75 years;
2. Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
3. Subjects with written informed consents.

Exclusion Criteria:

1. Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
2. Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
3. Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
4. Residents who are participating in other studies.

Where it's running

• Beijing Daxing District People Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Not yet recruiting

Study contacts

• Principal investigator: Yilong Wang, MD, PhD — Beijing Tiantan Hospital
• Study coordinator: Yuesong Pan, PhD
• Email: panys2000@163.com
• Phone: 010-59975807

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.