Improving math skills in children with learning disabilities

Interventions in Math Learning Disabilities: Cognitive and Neural Correlates

Not applicable Interventional Stanford University · NCT05201534

This study tests a new way to help children with learning disabilities improve their math skills by using different methods to see what works best for them.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment180 (estimated)
Ages6 Years to 12 Years
SexAll
SponsorStanford University Academic / other
Locations1 site (Palo Alto, California)
Trial IDNCT05201534 on ClinicalTrials.gov

What this trial studies

This study investigates the neurocognitive mechanisms that affect how children respond to interventions designed to enhance their numerical skills, particularly those with mathematical learning disabilities (MLD). Using a randomized controlled design, the study employs an integrated symbolic/non-symbolic intervention to improve the mapping between different representations of quantities. Researchers will develop computational models to explore individual differences in cognitive processes and brain plasticity that influence learning and retention of mathematical concepts. Performance will be assessed across various areas to understand the cognitive and neural mechanisms supporting numerical skill acquisition.

Who should consider this trial

Good fit: Ideal candidates are elementary school-aged children (6-12 years old) with identified mathematical learning disabilities or typically developing children with adequate math skills.

Not a fit: Patients with a history of neurological or psychiatric disorders, head injuries, or those on consistent psychiatric medications may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to more effective interventions for children struggling with math, improving their academic performance and confidence.

How similar studies have performed: Other studies have shown promise in using similar neurocognitive approaches to enhance learning outcomes in children, suggesting potential for success in this intervention.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Elementary school aged children starting from first grade (6-12 years old)
2. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
5. Normal or corrected-to-normal vision and no hearing impairments
6. Inclusion in MRI scan session: Right-handed

Exclusion Criteria:

1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
2. History of trauma involving head injury
3. Consistent psychiatric medications
4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)

Where this trial is running

Palo Alto, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Math Learning DisabilityChild DevelopmentDevelopmental DisabilityLearning DisabilitiesLearning DisabledLearning CurveMathematics DisorderDyscalculia
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.