Exploring how brain immune cells affect thinking problems in lupus patients
The Relationship Between Brain Macrophages and Cognitive Dysfunction in Systemic Lupus Erythematosus
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10885942
This study is looking at how certain immune cells in the brain might affect thinking and memory problems in people with lupus, and it aims to find out if understanding these cells can help improve cognitive function for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10885942 on ClinicalTrials.gov |
What this research studies
This research investigates the role of brain macrophages, a type of immune cell, in cognitive dysfunction associated with systemic lupus erythematosus (SLE). By analyzing tissue samples and using advanced techniques like single-cell RNA sequencing, the study aims to understand how these immune cells contribute to cognitive issues in lupus patients. The researchers are particularly focused on how changes in these macrophages correlate with behavioral deficits and how treatments may improve cognitive function. Patients may be involved in providing samples or participating in assessments related to their cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus who are experiencing cognitive dysfunction.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those not experiencing cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve cognitive function in lupus patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in cognitive dysfunction, suggesting that this approach may yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUDA, CARLA M — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: CUDA, CARLA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease