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Clinical trials and research at Yale University

• 233Clinical trials
• 2260NIH research projects
• 3New in 30 days
• 17Countries

Newest trials

All recruiting trials (newest 150 of 233)

• Pet imaging of sigma1 receptors in healthy adults

  This study tests two sigma-1 radiotracers, to see how well they image the brain in healthy adults and how reliably the imaging measurements work.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07915323

• Intradermal Flu Vaccine After All: Watching Immune Response in Skin and Blood

  This study tests whether giving the seasonal flu shot into the skin (instead of muscle) changes the immune response in healthy adults, cancer patients about to start immunotherapy, and people with post-acute infection syndromes.

  Recruiting Early Phase 1 Yale University · New Haven, Connecticut · NCT07908329

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand

  This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07800520

• Greater Occipital Nerve Blockade for Veterans with Post-Traumatic Headache

  This study tests whether injecting tiny amounts of anesthesia into the greater occipital nerve can reduce headache days for veterans with chronic post-traumatic headaches.

  Recruiting Phase 2 Yale University · West Haven, Connecticut · NCT07796074

• Adaptive Decision Support for Addiction Treatment: Testing a Care Tool for ED Doctors to Help Buprenorphine Use

  We’re testing a refined decision-support tool in emergency departments to help doctors prescribe buprenorphine to adults with moderate to severe opioid use disorder.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT07793383

• Semaglutide for Alcohol Use Disorder and Obesity: Testing 1.0 mg and 2.0 mg vs Placebo

  We’re testing two doses of semaglutide to see if they reduce alcohol craving and use in adults with alcohol use disorder and obesity compared with placebo.

  Recruiting at 2 sites Phase 1 Yale University · New Haven, Connecticut and 1 other locations · NCT07772960

• Real-time fMRI Neurofeedback for Anhedonia in Methadone-Treated Opioid Use Disorder

  This feasibility study tests a real-time fMRI neurofeedback approach to see if it helps reduce anhedonia in people on methadone for opioid use disorder.

  Recruiting Yale University · New Haven, Connecticut · NCT07768007

• Gaucher Disease: Following Patients on Standard Care to See How It Progresses

  This study will observe people with Gaucher disease who are receiving standard care to see how their condition changes over time and to explore the biology behind persistent or worsening disease.

  Recruiting Yale University · New Haven, Connecticut · NCT07758816

• Text2Quit-Kenya: a mobile message program to help ED patients quit tobacco

  Researchers will test a text message-based smoking-cessation program with Kenyan emergency department patients to see if it helps people quit and learn what works in this setting.

  Recruiting Yale University · Nairobi · NCT07734727

• How people disclose suicidal thoughts and get support in rural eastern Uganda

  This study tests how disclosure of suicidal thoughts or severe distress affects social support or harm, and who should be involved in future help.

  Recruiting Yale University · Mpunde, Buyende District · NCT07730307

• Intranasal oxytocin to help with pain after pituitary surgery

  This study tests whether intranasal oxytocin can reduce pain after pituitary surgery and improve recovery.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07730294

• Exercise program for adults with primary antibody deficiencies

  A 12-week app-guided exercise program is tested to see if it is safe, practical, and acceptable and whether it can improve quality of life and immune function for adults with primary antibody deficiencies.

  Recruiting at 2 sites Yale University · Milford, Connecticut and 1 other locations · NCT07698197

• Unified network for a Yale liquid biopsy repository

  This project tests collecting blood and tissue samples from Yale Cancer Center patients to build a shared liquid biopsy repository for current and future cancer research.

  Recruiting Yale University · New Haven, Connecticut · NCT07689864

• Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care

  This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.

  Recruiting Yale University · Old Saybrook, Connecticut · NCT07639060

• Psilocybin Therapy for Depression in Parkinson’s Disease

  This study tests whether psilocybin therapy can help reduce depressive symptoms in people with Parkinson’s disease.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07610369

• Music for Pain and Dementia: Group Drumming for people with early dementia and their caregivers

  This study tests whether group drumming can reduce pain and change brain activity in people with mild dementia or mild cognitive impairment and in their caregivers.

  Recruiting Yale University · New Haven, Connecticut · NCT07602283

• Engaging Latinos with Serious Mental Illness Using Culturally Responsive Peer Support

  This pilot tests whether culturally tailored, peer-delivered motivational interviewing can help Latinos with serious mental illness start or restart mental health care.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT07529509

• Syndemic-Adapted Medly Uganda for adults with HIV and hypertension

  This study tests whether the Syndemic-Adapted Medly Uganda (SAMU) program helps improve mental health screening and care for adults living with HIV and high blood pressure in Uganda.

  Recruiting at 3 sites Yale University · Kampala and 2 other locations · NCT07525271

• Integrating medications and brief counseling for alcohol use disorder into hepatology clinics

  This project will test a way to help hepatology clinic clinicians provide medicines and short counseling for people with alcohol use disorder and alcohol-associated liver disease.

  Recruiting Yale University · New Haven, Connecticut · NCT07525258

• Preoperative submaximal exercise testing to predict outcomes after moderate- to high-risk noncardiac surgery

  This study will test whether a brief submaximal cardiopulmonary exercise test done before moderate- to high-risk noncardiac surgery can help predict which adults over 45 are more likely to have problems after surgery.

  Recruiting Yale University · New Haven, Connecticut · NCT07519733

• Membrane potential mapping with a radioactive PET tracer

  Researchers will test 18F-TPP with PET imaging to see how it behaves in the body and to map membrane potential in healthy volunteers.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07506616

• Imaging PDE4B in people with PTSD or Alcohol Use Disorder using [18F]PF974

  This study tests whether a PET tracer can image PDE4B in adults with PTSD or alcohol use disorder to better understand brain targets related to these conditions.

  Recruiting Yale University · New Haven, Connecticut · NCT07488819

• Language Network Prehab with fMRI Neurofeedback before Glioma Surgery

  This study tests whether brief fMRI neurofeedback before glioma surgery can help shift language brain activity away from tumor-affected areas.

  Recruiting Yale University · New Haven, Connecticut · NCT07488780

• EMS-initiated buprenorphine for opioid use disorder

  This study tests whether starting buprenorphine in EMS encounters helps people stay in treatment or connect to ongoing care for opioid use disorder.

  Recruiting at 3 sites Yale University · Oakland, California and 2 other locations · NCT07475728

• [18F]GATT-44 PET scan to image the brain's GABA transporter (GAT-1).

  This will test whether the experimental PET tracer [18F]GATT-44 can safely image the brain's GAT-1 and how the tracer behaves in healthy adults.

  Recruiting Early Phase 1 Yale University · New Haven, Connecticut · NCT07457736

• Neural Mechanisms of the Social Brain

  We’re testing how two brains sync during social interaction in healthy adults using targeted brain stimulation and brain imaging.

  Recruiting Yale University · New Haven, Connecticut · NCT07457567

• How quickly basivertebral nerve ablation relieves vertebrogenic low back pain

  This study will follow people with vertebrogenic low back pain who are getting basivertebral nerve ablation to see how quickly and how much their pain and function improve over two years.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT07433634

• Skin color matching in head and neck reconstruction with RECELL on de-epithelialized tissue

  This study tests if using RECELL autologous cell suspension with de-epithelialized tissue provides better skin color match for head and neck reconstruction than standard grafts.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT07431099

• Capivasertib with preventive care for rash and diarrhea in metastatic HR+/HER2- breast cancer

  This phase II trial tests whether antihistamine and loperamide prophylaxis can reduce rash and diarrhea in adults starting capivasertib with fulvestrant.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07426822

• Portable Rehabilitation Interface (PoRI) for improving hand function after stroke

  This trial tests the PoRI portable hand-rehabilitation device to see if it helps people who recently had a stroke regain hand motor function compared with standard hand therapy.

  Recruiting Yale University · Milford, Connecticut · NCT07407023

• Sex differences in how menthol e-cigarettes appeal to people who smoke

  This study tests whether men and women differ in how menthol e-cigarettes with or without nicotine appeal to smokers who have used e-cigarettes before.

  Recruiting Yale University · New Haven, Connecticut · NCT07398976

• Telehealth treatment for opioid use disorder in adults

  This trial tests whether using the RecoveryPad telehealth platform helps adults with moderate to severe opioid use disorder.

  Recruiting Yale University · New Haven, Connecticut · NCT07362082

• Suicide prevention in primary care clinics in Nepal

  This project will try a package of tools and training to help primary care providers in Bagmati Province, Nepal, better find and manage patients at risk of suicide.

  Recruiting Yale University · Dolakhā · NCT07362056

• Colorectal Cancer Screening Outreach for Better Adherence

  This trial tests a bundled messaging approach to help adults at risk complete colorectal cancer screening.

  Recruiting Yale University · New Haven, Connecticut · NCT07345676

• Using a sleep medication to help people with obstructive sleep apnea tolerate CPAP

  The trial will test whether giving the sleep medicine eszopiclone to people with obstructive sleep apnea (AHI ≥10/hour) helps them stick with CPAP and improves thinking skills.

  Recruiting Phase 3 Yale University · North Haven, Connecticut · NCT07332442

• Best timing for 24-hour urine copper after a brief treatment break

  This will see if a 24-hour urine copper test taken after a short, supervised pause in treatment reflects body copper levels in stable Wilson disease patients.

  Recruiting Yale University · New Haven, Connecticut · NCT07301216

• Mass-based drug screening to guide personalized HIPEC for high-grade appendiceal and colorectal cancer with peritoneal spread.

  This tests whether a lab-based mass response test on tumor biopsies can pick the best chemotherapy to use during repeated HIPEC for people with unresectable peritoneal metastases from high-grade appendiceal or colorectal cancer.

  Recruiting Yale University · New Haven, Connecticut · NCT07291180

• Planned surgery or focused local treatment after chemo for metastatic upper-GI adenocarcinoma with undetectable ctDNA

  This test sees if adding planned surgery or local treatments after three months of chemotherapy helps people with metastatic upper-gastrointestinal adenocarcinomas who have undetectable ctDNA.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07282912

• Using the SGLT2 pill dapagliflozin for hospitalized adults with heart failure who develop acute kidney injury.

  This trial will test whether adding the SGLT2 pill dapagliflozin to usual care helps hospitalized adults with heart failure who develop acute kidney injury.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07273838

• Measuring calcinosis cutis burden on CT scans

  This project will test software that measures calcinosis cutis on CT images for adults with systemic sclerosis who are receiving sodium thiosulfate as part of their care.

  Recruiting Yale University · New Haven, Connecticut · NCT07228429

• Non-invasive central venous pressure estimation using an external jugular venous occlusion device

  This trial tests whether a non-invasive neck device (CPMX2) can estimate central venous pressure in adult cardiac ICU patients who already have invasive CVP monitoring.

  Recruiting Yale University · New Haven, Connecticut · NCT07226479

• Life at 100.4: a social virtual reality education program for adolescents and young adults with cancer and their caregivers

  This project will try a virtual reality program called Life at 100.4 to teach teens and young adults with new cancer diagnoses and their caregivers about febrile neutropenia.

  Recruiting Yale University · New Haven, Connecticut · NCT07224204

• Shared decision-making to prevent or treat HIV for people with recent justice involvement

  This project tests whether offering a shared decision-making 'patient choice' menu alongside standard patient navigation helps people with recent justice involvement start HIV prevention (PrEP) or treatment (ART) and begin substance use disorder care.

  Recruiting at 4 sites Yale University · New Haven, Connecticut and 3 other locations · NCT07223398

• Parent-led programs to help teens with anxiety

  This study tests whether a parent-only program called SPACE helps adolescents with anxiety more than a parent education program (PES) by comparing symptoms before, after, and at follow-up across 12 sessions.

  Recruiting Yale University · New Haven, Connecticut · NCT07219992

• Long-term testing of an etonogestrel implant placed over the shoulder blade

  This project will test whether placing the etonogestrel contraceptive implant over the shoulder blade gives steady drug levels and acceptable side effects for people assigned female at birth aged 18 to 45.

  Recruiting at 2 sites Phase 2 Yale University · Aurora, Colorado and 1 other locations · NCT07201402

• Overnight double-balloon catheter for cervical ripening before dilation and evacuation

  This will test whether using an overnight double-balloon catheter works better than overnight osmotic dilators to prepare the cervix for people having a second‑trimester D&E.

  Recruiting Yale University · New Haven, Connecticut · NCT07200115

• Portable MRI to detect brain injury after cardiac arrest

  This will test whether a bedside portable MRI can detect hypoxic-ischemic brain injury in adults who are unresponsive after resuscitation from cardiac arrest.

  Recruiting Yale University · New Haven, Connecticut · NCT07197918

• Monthly extended-release Buprenorphine given via a mobile clinic for opioid use disorder

  This project tests whether monthly extended-release subcutaneous buprenorphine can be feasibly and acceptably delivered from a mobile pharmacy clinic to people with opioid use disorder.

  Recruiting Phase 4 Yale University · New Haven, Connecticut · NCT07176351

• CUE-101 with pembrolizumab for locally advanced HPV‑16 positive oropharyngeal cancer

  This trial tests whether CUE-101 alone or combined with pembrolizumab before definitive therapy helps people with newly diagnosed, locally advanced HPV‑16 positive oropharyngeal cancer who are HLA‑A*02:01 positive.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07172256

• Home fingerstick oral glucose tolerance test for people at risk for or newly diagnosed with Type 1 diabetes

  This project tries a self‑administered fingerstick oral glucose tolerance test at home to see if it gives similar results to the standard in‑clinic venous test for people at risk for or newly diagnosed with Type 1 diabetes.

  Recruiting Yale University · New Haven, Connecticut · NCT07155252

• Psilocybin for chronic pain in people who smoke

  This pilot study tests whether a single psilocybin dose is safe and might help reduce chronic pain and boost motivation to quit smoking in people who smoke and have chronic pain.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut and 1 other locations · NCT07118332

• Stepped care to improve MOUD retention for women with OUD, PTSD, and IPV history

  This study tests whether a stepped care program combining Present-Centered Therapy and HOPE can help women on medication for opioid use disorder who experienced intimate partner violence stay in treatment longer and reduce PTSD-related problems.

  Recruiting at 2 sites Yale University · Bridgeport, Connecticut and 2 other locations · NCT07115030

• Iadademstat with SBRT and atezolizumab for extensive-stage small cell lung cancer

  This phase 1b test checks if adding iadademstat to stereotactic body radiotherapy (SBRT) and the immunotherapy atezolizumab is safe and helps control disease in adults with residual, recurrent, or progressive extensive-stage small cell lung cancer after platinum chemotherapy.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07113691

• Effect of Moderate-Intensity Exercise on OCD Symptoms and Cognitive Flexibility

  This study tests whether 20 minutes of moderate-intensity cycling can help adults with OCD feel less distress and urges while improving cognitive flexibility compared with a low-intensity activity.

  Recruiting Yale University · New Haven, Connecticut · NCT07103902

• Luspatercept plus darbepoetin for lower-risk, transfusion-dependent MDS without an SF3B1 mutation

  This trial will try combining luspatercept with darbepoetin to reduce red blood cell transfusions in adults with lower-risk, transfusion-dependent MDS who are SF3B1 wild-type and have endogenous EPO below 500 IU/L.

  Recruiting Phase 2 Yale University · New Haven, Connecticut and 3 other locations · NCT07096297

• Lifestyle, exercise, and nutrition program to improve response in triple-negative breast cancer

  This will test whether weekly remote nutrition counseling and a home-based exercise program can help women with stage II–III triple-negative breast cancer have no remaining tumor in the breast after chemo-immunotherapy before surgery.

  Recruiting Yale University · New Haven, Connecticut · NCT07066189

• Digital mindfulness program for young adults with type 1 diabetes

  This program will test the Calm Health mindfulness app to see if guided digital mindfulness and personalized feedback can help 18–30-year-olds with type 1 diabetes better manage stress, sleep, and blood sugar.

  Recruiting Yale University · New Haven, Connecticut · NCT07062887

• T1CARE: A program to address social needs for young adults with Type 1 diabetes

  This program will see if giving young adults with Type 1 diabetes support from a Community Health Navigator helps resolve social needs and improve diabetes-related well-being and care.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT07059806

• Consolidative local surgery for oligo‑metastatic urothelial (bladder) cancer

  This trial will see if adding surgery to remove the bladder tumor (and any resectable metastases) after a good response to enfortumab vedotin–based therapy helps people with locally advanced or oligo‑metastatic urothelial cancer.

  Recruiting Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07048457

• Off-label semaglutide for alcohol use disorder in people with HIV (pilot 3)

  This pilot will test whether adding off-label semaglutide plus medical management and pharmacist-delivered counseling reduces drinking in people with HIV who have alcohol use disorder and take five or more medications.

  Recruiting Phase 2 Yale University · Decatur, Georgia · NCT07040592

• Varenicline to help adults stop vaping

  This trial tests whether the smoking-cessation pill varenicline helps adults who vape daily quit e-cigarettes.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07040566

• Looking at lymph nodes in kidney cancer

  This project will collect blood and tissue, including tumor and draining lymph nodes, from adults with known or suspected kidney cancer who are having routine procedures to see how T cells in lymph nodes interact with tumors.

  Recruiting Yale University · New Haven, Connecticut · NCT07038733

• Apremilast vs. placebo for adults with alcohol use disorder

  This study tests whether apremilast 60 mg daily helps adults with alcohol use disorder reduce drinking compared with a placebo.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07029529

• AB821 for adults with advanced melanoma and other immune-responsive solid tumors

  This will test whether AB821 given every two weeks is safe and shows early anti-tumor activity in adults with recurrent locally advanced or metastatic melanoma or other immune-responsive solid tumors.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07027488

• At-home light therapy for chemo-related nerve pain in childhood cancer survivors

  This study tests whether a six-week at-home light therapy program can help childhood cancer survivors who have chemotherapy-induced peripheral neuropathy.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT07019259

• Imaging demyelination with [18F]3F4AP PET

  This test uses a PET tracer called [18F]3F4AP in adults with demyelinating conditions and in healthy volunteers to see how the tracer moves through the body.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06999434

• Aiming to see if adalimumab can slow brain changes linked to synucleinopathy in people with REM sleep behavior disorder

  This phase 2 trial tests whether the drug adalimumab, compared with placebo, can slow brain changes and progression toward Parkinson-like symptoms in people with idiopathic REM sleep behavior disorder.

  Recruiting at 10 sites Phase 2 Yale University · Los Angeles, California and 17 other locations · NCT06996652

• T-cell therapies talquetamab and teclistamab to clear minimal residual disease after transplant in newly diagnosed myeloma (ROTATE)

  This tests whether giving talquetamab to patients who are MRD positive after induction and transplant, and switching to teclistamab if MRD doesn't clear, can make them MRD negative.

  Recruiting at 3 sites Phase 2 Yale University · New Haven, Connecticut and 2 other locations · NCT06993675

• Help adults with type 1 diabetes build and keep regular exercise habits

  This project will try a smartphone app plus personalized coaching, fitness-watch data, and continuous glucose monitoring insights to help adults with type 1 diabetes exercise more often and more confidently.

  Recruiting Yale University · New Haven, Connecticut · NCT06967701

• Optimizing malaria and HIV treatment for children in Busia and Kampala

  We will test whether dolutegravir affects growth and how it interacts with common malaria medicines in children with and without HIV, following them for two years in Busia and Kampala.

  Recruiting at 2 sites Phase 4 Yale University · Kampala and 1 other locations · NCT06967519

• Mobile app to help reduce problem gambling

  This study is testing whether a mobile app can help people with gambling problems feel better when used alongside regular treatment.

  Recruiting at 6 sites Yale University · Denver, Colorado and 5 other locations · NCT06963931

• Sacituzumab govitecan with nivolumab, with or without relatlimab, for metastatic triple-negative breast cancer

  This trial tests whether adding nivolumab alone or nivolumab plus relatlimab to sacituzumab govitecan helps people with metastatic triple-negative breast cancer who have had one prior line of chemotherapy.

  Recruiting Phase 1/2 Yale University · New Haven, Connecticut · NCT06963905

• Improving opioid treatment and HIV prevention in prisons

  This study is trying to find out what makes it hard to provide opioid treatment in prisons in Tajikistan, Kyrgyzstan, Moldova, and Georgia, so that they can improve care for people with addiction and help prevent HIV.

  Recruiting at 4 sites Yale University · New Haven, Connecticut and 4 other locations · NCT06962033

• Skipping chemotherapy for certain ER-positive, HER2-negative, node-positive breast cancers while using ribociclib with hormone therapy

  This trial tests whether skipping adjuvant chemotherapy and treating with ribociclib plus hormone therapy helps people with ER-positive, HER2-negative, node-positive breast cancer and a low Oncotype DX score stay on their CDK4/6 treatment.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06953882

• Acute THC effects in older adults

  This project will see if single low or medium doses of THC cause stronger short-term effects on thinking, mood, and heart function in older adults compared with younger adults.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06948136

• How subcortical arousal affects perception

  This study will test whether activity in deep arousal circuits changes how healthy adults and people with epilepsy (who have thalamic electrodes) perceive sights, sounds, and touch using fMRI, eye measurements, behavioral tests, and direct thalamic recordings and stimulation.

  Recruiting at 7 sites Yale University · New Haven, Connecticut and 7 other locations · NCT06934356

• Promoting Palliative Care for Heart Failure Patients

  This trial tests a clinical decision tool that helps clinicians refer hospitalized heart failure patients to palliative care sooner to see if it improves care alignment with patients' goals.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT06933875

• ctDNA-guided elacestrant for ER+ breast cancer

  This trial will test whether giving elacestrant for one year to people with ER+, stage IIB/III breast cancer who have a positive ctDNA test after finishing endocrine therapy can eliminate hidden cancer and lower the chance of recurrence.

  Recruiting at 6 sites Phase 2 Yale University · New Haven, Connecticut and 6 other locations · NCT06923527

• Mobile app program to help cancer patients cope

  A mobile app program called Tools for Coping with Cancer Calm Health is being tested to see if it helps adults with a cancer history feel better and cope with distress.

  Recruiting Yale University · New Haven, Connecticut · NCT06923501

• Fezolinetant for hot flashes in women with early-stage, hormone receptor–positive breast cancer on endocrine therapy

  This trial will test whether taking fezolinetant 45 mg daily can reduce moderate-to-severe hot flashes in women with early-stage, HR+ breast cancer who are on tamoxifen or aromatase inhibitors.

  Recruiting Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06917313

• Comparing once vs. twice daily radiation therapy for lymphoma treatment

  This study is testing whether giving radiation therapy once or twice a day can help people with relapsed lymphoma feel better and respond to treatment.

  Recruiting Yale University · New Haven, Connecticut · NCT06898905

• Maternal nutrition and health literacy program — Tamale, Ghana

  This project tests a nutrition education program using local foods to help first-time pregnant women in northern Ghana eat a wider variety of foods, increase protein and iron intake, and support healthy weight gain.

  Recruiting Yale University · Tamale, Northern Region · NCT06898346

• Understanding whether the body stores sodium without accompanying water

  Test if switching peritoneal dialysis fluid to a water-only dextrose solution versus standard dialysis fluid causes measurable water-free sodium storage or release in people on peritoneal dialysis.

  Recruiting Yale University · New Haven, Connecticut · NCT06872645

• Home-based ear (taVNS) stimulation for IBS pain

  This trial will test whether a home-based ear vagus nerve stimulation device, used twice daily for six weeks, helps reduce pain and symptoms in 18–29-year-olds with IBS compared with a look‑alike sham device.

  Recruiting Yale University · New Haven, Connecticut · NCT06847360

• Frontopolar tDCS to improve safety learning and extinction in OCD

  This will test whether brief frontopolar transcranial direct current stimulation (tDCS) can help adults with OCD improve extinction learning and safety-signal processing.

  Recruiting Yale University · New Haven, Connecticut · NCT06834217

• Transcranial direct current stimulation for laryngeal dystonia

  This trial will try transcranial direct current stimulation (tDCS) in people with laryngeal dystonia to see if it improves voice control.

  Recruiting Yale University · New Haven, Connecticut · NCT06830174

• Understanding pain avoidance in people with opioid use disorder

  This study looks at how people with opioid use disorder learn to avoid pain compared to healthy individuals to better understand their condition.

  Recruiting Yale University · New Haven, Connecticut · NCT06800703

• Improving decision support for opioid addiction treatment

  This study is testing ways to improve a system that helps emergency department staff give buprenorphine to people with opioid addiction to make sure they get the right treatment.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT06799117

• Examining stress and pain in individuals living with HIV

  This study is testing how stress and pain affect people living with HIV, especially those who also struggle with substance use and depression, to see how these factors are connected.

  Recruiting Yale University · New Haven, Connecticut · NCT06784908

• Gut fermentation and metabolism in teens and young adults with obesity

  This will test whether giving lactulose to teens and young adults with obesity and insulin resistance changes gut fermentation in ways that lower fat release from fat tissue and reduce appetite.

  Recruiting Yale University · New Haven, Connecticut · NCT06768827

• Testing a new drug for patients with metastatic HER2-negative breast cancer

  This study is testing a new drug called T-DXd to see if it can help adults with metastatic HER2-negative breast cancer feel better and improve their treatment outcomes.

  Recruiting at 3 sites Phase 2 Yale University · New Haven, Connecticut and 2 other locations · NCT06750484

• Long-term follow-up on treatments for major depression using Spravato or IV ketamine

  This study is looking at how well Spravato and IV ketamine work for treating major depression over five years, focusing on how patients feel about the treatments and their long-term safety.

  Recruiting at 6 sites Yale University · Milford, Connecticut and 7 other locations · NCT06725277

• Comparing the effectiveness of nasal Esketamine and IV Ketamine for treating depression

  This study is testing whether a nasal spray called Esketamine works better than IV Ketamine for people with treatment-resistant depression and how well patients tolerate each option.

  Recruiting at 6 sites Phase 3 Yale University · Milford, Connecticut and 7 other locations · NCT06713616

• Examining the effects of social disconnection on the brain

  This study is testing how feelings of loneliness and isolation affect the brains of people aged 55 and older over time.

  Recruiting Yale University · New Haven, Connecticut · NCT06705348

• Remote video therapy for pelvic floor muscle issues

  This study is testing if a video-based therapy program can help people with pelvic floor issues like urinary incontinence feel better and improve their quality of life.

  Recruiting Yale University · New Haven, Connecticut · NCT06689891

• Adding a PrEP decision aid to counseling at sexual and reproductive health clinics

  This project will test whether giving a PrEP decision aid to women at sexual and reproductive health clinic visits helps them choose and start the best HIV prevention option.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06684613

• MDMA to improve social understanding in borderline personality disorder

  This trial will test whether MDMA can improve social thinking and relationships in adults with borderline personality disorder.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06683014

• Investigating the effects of DMT on depression

  This study is testing whether DMT can help people with depression feel better and how it affects their brain activity compared to healthy volunteers.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06671977

• High-flow nasal cannula versus noninvasive ventilation after extubation in people with systolic heart failure

  This pilot will test whether high-flow nasal cannula or noninvasive ventilation after extubation better prevents reintubation in adults with systolic heart failure who were on a ventilator.

  Recruiting Yale University · New Haven, Connecticut · NCT06671015

• App to help high school students quit vaping

  This study is testing whether the Kick-Nic! app can help high school students quit vaping better than just using a regular website with quitting resources.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06662305

• Providing free continuous glucose monitors to improve diabetes management

  This study is testing if giving free continuous glucose monitors to adults with poorly controlled type 2 diabetes can help them manage their blood sugar better and improve their quality of life.

  Recruiting Yale University · New Haven, Connecticut · NCT06658067

• Guselkumab treatment for Hailey-Hailey disease

  This study is testing if a medication called guselkumab, usually used for psoriasis, can help people with Hailey-Hailey disease improve their skin condition.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06651489

• Examining brain activity patterns related to opioid relapse during treatment

  This study is testing how brain activity patterns might predict the risk of relapse to opioid use in people who have just started treatment with methadone or buprenorphine.

  Recruiting at 2 sites Yale University · Hartford, Connecticut and 1 other locations · NCT06651333

• Treatment for fathers dealing with substance misuse and family violence

  This study tests if the Fathers for Change program can help dads struggling with substance misuse and family violence more than regular drug counseling.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06650267

• fMRI pilot: how THC affects memory and learning in young to middle-aged adults

  This will see if a single dose of THC temporarily impairs memory and learning in young to middle-aged adults who use cannabis.

  Recruiting Phase 2 Yale University · Hartford, Connecticut · NCT06647524

• Investigating how sleep affects smoking cessation

  This study is testing whether improving sleep can help adults trying to quit smoking stay smoke-free longer by comparing two different support methods.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06609369

• Digoxin for NASH with stage 2–3 fibrosis

  This trial will see if taking once-daily digoxin helps clear NASH and reduce liver scarring in adults with biopsy-confirmed NASH and stage 2–3 fibrosis.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06588699

• Effects of alcohol on stress and brain chemistry

  This study is testing how drinking alcohol affects stress and brain chemistry in people to find better ways to help reduce harmful drinking habits.

  Recruiting Yale University · New Haven, Connecticut and 1 other locations · NCT06584448

• Using THC and CBD to treat chronic pain and opioid cravings

  This study is testing if a mix of THC and CBD can help people with chronic pain and opioid cravings feel better while they are on methadone.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06544291

• Rapid-start HIV treatment to reduce stigma for people who inject drugs

  This project will test whether starting HIV treatment quickly (within 7 days) reduces stigma and improves care for people who inject drugs, including those in prison.

  Recruiting at 2 sites Yale University · Kajang and 2 other locations · NCT06541028

• Improving pain care for veterans using a new pathway

  This study is testing a new way to help case managers support veterans in managing their pain better by comparing standard training to extra help in using a specific pain care program.

  Recruiting Yale University · West Haven, Connecticut · NCT06526143

• Pilot intervention for HIV patients focusing on alcohol use and medication effects

  This study tests a new program to help HIV-positive patients who drink alcohol manage their medications better and reduce risks like falls and memory problems.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06513819

• Comparing standard and high doses of buprenorphine for opioid use disorder treatment

  This study is testing whether a standard or higher dose of buprenorphine helps people with opioid use disorder start treatment and feel better within 10 days.

  Recruiting at 5 sites Phase 3 Yale University · Oakland, California and 4 other locations · NCT06494904

• Speech motor learning and retention in adults using brain stimulation and fMRI

  This study tests whether learning new speech movements and retaining them depend on brain areas beyond the mouth and speech muscles, by using brain stimulation and brain imaging to see how the brain changes relate to getting and keeping new speech skills.

  Recruiting Yale University · New Haven, Connecticut · NCT06492252

• Understanding how the brain learns and retains speech motor skills

  This study is trying to see how different parts of the brain help people learn and remember how to speak by using special techniques to look at brain activity.

  Recruiting Yale University · New Haven, Connecticut · NCT06491823

• Developing a new method to screen medications for Alcohol Use Disorder

  This study is testing a new way to see how well people with Alcohol Use Disorder can resist drinking when faced with alcohol cues and rewards for not drinking.

  Recruiting Yale University · New Haven, Connecticut · NCT06489782

• Testing a new model of speech motor learning and retention

  This study is testing a new way to help people learn and remember how to speak by looking at how different parts of the brain work together during speech practice.

  Recruiting Yale University · New Haven, Connecticut · NCT06467305

• Testing a new model for learning and retaining speech motor skills

  This study is testing a new way to help people learn and remember how to speak by looking at how different parts of the brain work together during speech practice.

  Recruiting Yale University · New Haven, Connecticut · NCT06467292

• Investigating the effects of psilocybin on migraine headaches

  This study is testing if psilocybin can help reduce migraine headaches by looking at how it affects brain activity and other factors in people with migraines and healthy individuals.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT06464367

• Registry for pediatric patients with PTEN Hamartoma Tumor Syndrome

  This study is collecting information from families of children with PTEN Hamartoma Tumor Syndrome to better understand the condition and improve care for those affected.

  Recruiting Yale University · Istanbul · NCT06462430

• Psilocybin treatment for individuals with various psychiatric symptoms

  This study is testing if a single dose of psilocybin can help people with different mental health issues like depression, anxiety, and PTSD feel better and improve their daily functioning.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06442423

• Neurofeedback for managing food cravings in overweight individuals

  This study tests if neurofeedback can help overweight people with strong food cravings change how their brains respond to food and improve their eating habits.

  Recruiting Yale University · New Haven, Connecticut · NCT06426693

• GLP-1 analogue treatment for obesity in young adults with type 1 diabetes

  This study is testing if a weight-loss medication can help young adults with type 1 diabetes and obesity improve their health over a year.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06411210

• Mobile app to help recovery after hip, knee, or spine surgery

  We will test a mobile app that prompts in-bed conditioning exercises to help people over 65 recover after hip fracture fixation, spinal fusion, or total hip/knee replacement.

  Recruiting Yale University · New Haven, Connecticut · NCT06407427

• Imaging depression in people with Parkinson's disease

  This study looks at how depression affects the brains of people with Parkinson's disease and tests if a single dose of ketamine can help improve their symptoms.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06402955

• Imaging brain changes in PTSD and Alcohol Use Disorder

  This study is testing if brain imaging can help us understand how a specific marker is related to PTSD and Alcohol Use Disorder in people who have these conditions.

  Recruiting Yale University · New Haven, Connecticut · NCT06371404

• Evaluating how genetics affect the effectiveness of oral contraceptive pills

  This study is testing if a specific genetic variation affects how well oral contraceptive pills work for women aged 18-45.

  Recruiting at 2 sites Phase 4 Yale University · Aurora, Colorado and 1 other locations · NCT06334315

• Exploring gut immunity's role in neurologic diseases

  This study is trying to see how immune cells in the gut might affect diseases like Multiple Sclerosis and Parkinson's by looking at tissue samples from people having a colonoscopy.

  Recruiting Yale University · North Haven, Connecticut · NCT06329453

• Comparing office-based methadone and buprenorphine for treating opioid use disorder

  This study is testing whether getting methadone or buprenorphine in a doctor's office helps people with opioid use disorder stay in treatment longer.

  Recruiting at 6 sites Phase 4 Yale University · Oakland, California and 5 other locations · NCT06323824

• Using brain stimulation to improve social understanding in autism

  This study is testing if a type of brain stimulation can help young adults with autism understand social situations better.

  Recruiting Yale University · Hartford, Connecticut · NCT06214065

• Understanding Diuretic Resistance in Heart Failure

  This study is testing if adding ammonium chloride to the usual diuretic treatment can help people with heart failure who struggle to get rid of excess fluid.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06209359

• Tracking brain changes in people undergoing treatment for opioid use disorder

  This study is trying to see how brain changes in people getting treatment for opioid use disorder with methadone happen over time to help improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT06207162

• Evaluating the effectiveness of RSV vaccines in real-world settings

  This study is testing how well RSV vaccines work in the real world for infants who get respiratory illnesses.

  Recruiting Yale University · New Haven, Connecticut · NCT06172660

• Peer mentoring to improve glucose monitor use in Black and Latinx adolescents with diabetes

  This study is testing a peer mentoring program to help Black and Latinx teens with type 1 diabetes use continuous glucose monitors better to manage their condition.

  Recruiting Yale University · New Haven, Connecticut · NCT06171412

• Using Chlorhexidine Gluconate to improve outcomes for patients with chronic suprapubic catheters

  This study is testing if a special solution called Chlorhexidine can help people with chronic suprapubic catheters avoid urinary infections and improve their quality of life during catheter changes.

  Recruiting Yale University · New Haven, Connecticut · NCT06163469

• Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

  This study is testing if psilocybin can help improve brain function in people struggling with opioid use disorder.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06160284

• Using Transcranial Magnetic Stimulation to Treat Depression in Autism

  This study is trying out a new brain treatment to see if it can help people with autism who also have depression feel better.

  Recruiting Yale University · New Haven, Connecticut · NCT06142955

• Effects of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers

  This study is testing if a new drug called mavoglurant can help heavy drinkers with Alcohol Use Disorder reduce their cravings and drinking.

  Recruiting at 2 sites Phase 1 Yale University · New Haven, Connecticut and 1 other locations · NCT06136195

• Improving blood pressure control through community partnerships and remote monitoring

  This study is testing if adding support from community health workers to a remote blood pressure management program can help people control their blood pressure better than just using the program alone.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 3 other locations · NCT06122246

• Combining SBRT with Relugolix for Prostate Cancer Treatment

  This study is testing if combining a type of radiation therapy with a new oral medication can help men with certain prostate cancer types achieve better treatment results while keeping their sexual and hormonal functions healthier.

  Recruiting at 4 sites Phase 2 Yale University · New Haven, Connecticut and 3 other locations · NCT06111781

• Combining Sipuleucel-T with Bipolar Androgen Therapy for Advanced Prostate Cancer

  This study is testing if combining a new treatment with testosterone injections and Sipuleucel-T can boost the immune response and help men with advanced prostate cancer feel better.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06100705

• Determining the nicotine threshold for smokers

  This study is testing how different amounts of nicotine affect smokers' choices and feelings to see what levels are most rewarding for them.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT06096714

• Using Metformin to Improve Kidney Health in FSGS

  This study is testing if taking extended-release Metformin along with regular treatment can help improve kidney health in people with Focal Segmental Glomerulosclerosis (FSGS).

  Recruiting at 2 sites Phase 1/2 Yale University · New Haven, Connecticut and 1 other locations · NCT06090227

• Comparing e-cigarettes and nicotine pouches for reducing cigarette smoking

  This study is testing whether e-cigarettes or nicotine pouches help adult smokers cut down on their cigarette use over four weeks.

  Recruiting Yale University · New Haven, Connecticut · NCT06077240

• Intervention for fathers to reduce family violence and improve child mental health

  This study tests if a new program for fathers can better reduce family violence and improve the mental health of children who have been affected by it compared to standard programs.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT06074068

• Psychedelic DMT for Alcohol Use Disorder

  This trial will test whether a single psychedelic dose of DMT plus a short course of psychotherapy helps people with Alcohol Use Disorder drink less.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06070649

• Understanding genetics in cannabis use disorder and response to cannabinoids

  This study is testing how genetics affect the risk of cannabis use disorder and how people respond to a treatment with Delta-9-THC compared to a placebo.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT06058702

• Effects of ultrasound treatment on insulin sensitivity in diabetes

  This study is testing whether ultrasound treatment can help improve insulin sensitivity in people with Type 2 diabetes.

  Recruiting Yale University · New Haven, Connecticut · NCT06042517

• Registry for general anesthesia use in cesarean deliveries

  This study looks at how general anesthesia is used during cesarean deliveries to see what factors affect its use and how it impacts mothers and babies.

  Recruiting at 34 sites Yale University · Little Rock, Arkansas and 34 other locations · NCT06030063

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (newest 40 of 2260)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)

  A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.

  NIH research Yale University · New Haven, United States · NIH-11638490

• Community Health Worker–Led Hypertension Prevention and Control in Nepal

  A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.

  NIH research Yale University · New Haven, United States · NIH-11631225

• Community health worker-led hypertension prevention and control in Nepal

  A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.

  NIH research Yale University · New Haven, United States · NIH-11631224

• Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine

  A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.

  NIH research Yale University · New Haven, United States · NIH-11623580

• Behavioral and neural links between spoken language sounds and written words in young children

  This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.

  NIH research Yale University · New Haven, United States · NIH-11618515

• Understanding how autoimmunity causes myasthenia gravis

  This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.

  NIH research Yale University · New Haven, United States · NIH-11617060

• Digital-first heart failure care delivery in Uganda

  A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.

  NIH research Yale University · New Haven, United States · NIH-11616481

• Digital-first heart failure care delivery in Uganda

  A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.

  NIH research Yale University · New Haven, United States · NIH-11616480

• Digital-first HF care delivery in Uganda

  A new, phone-enabled program in Uganda aims to help people with heart failure manage their symptoms at home to feel better and live longer.

  NIH research Yale University · New Haven, United States · NIH-11616479

• Newborn screening: using gene and metabolite data to refine true vs false positives

  A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.

  NIH research Yale University · New Haven, United States · NIH-11608554

• Functional screen of hydrocephalus and heart-disease genes in a frog model

  A study uses frog embryos to test how human genetic changes might cause congenital hydrocephalus and related heart defects, with the goal of understanding why these conditions occur.

  NIH research Yale University · New Haven, United States · NIH-11608553

• Adapting mHealth to help older people with HIV stay in care in Ukraine

  A patient-friendly plan to adapt a smartphone-based support tool to help older adults living with HIV in Ukraine stay adherent to treatment and connected to care.

  NIH research Yale University · New Haven, United States · NIH-11608506

• East Palestine Train Derailment Health Research Program

  A Yale-led study is examining how the derailment outdoors and its water contamination may affect the health of nearby residents, especially children, by bringing together data and community voices to map exposure and health information.

  NIH research Yale University · New Haven, United States · NIH-11607901

• Pathogenic T cells in discoid lupus erythematosus

  A doctor-scientist at Yale is studying why certain immune T cells cause skin damage in discoid lupus, with the goal of finding ways to reduce scarring and improve health for patients, especially African American women.

  NIH research Yale University · New Haven, United States · NIH-11607165

• Understanding how immune checkpoint drugs can trigger inflammatory arthritis in cancer patients

  This research looks at why some cancer patients develop inflammatory arthritis after PD-1 inhibitor therapy and what could be done to prevent it.

  NIH research Yale University · New Haven, United States · NIH-11603643

• Shared decision-making to prevent cancer in South Africa

  A multi-level, school-based program in South Africa helps families, teachers, and health workers make informed choices to prevent cervical and related cancers, especially where HIV is common.

  NIH research Yale University · New Haven, United States · NIH-11603112

• Scaling up pangenome graphs to study complex genetic changes in Alzheimer's disease

  A research project at Yale aims to improve how we map big genetic variations to understand Alzheimer’s disease.

  NIH research Yale University · New Haven, United States · NIH-11596496

• Macrophages and the developing liver in Alagille syndrome

  This project explores how immune cells called macrophages influence liver development in young patients with Alagille syndrome.

  NIH research Yale University · New Haven, United States · NIH-11596385

• Ketamine to boost fear extinction and memory on PTSD patients

  A study testing whether ketamine can help people with PTSD better relearn and forget fear when given in a guided treatment plan.

  NIH research Yale University · New Haven, United States · NIH-11592530

• CREBRF gene and diabetes risk in American Samoan pregnancies

  This project follows 350 pregnant American Samoan women to understand how a specific gene variant may influence diabetes risk during and after pregnancy.

  NIH research Yale University · New Haven, United States · NIH-11592385

• An mHealth plan to tackle mental illness, high blood pressure, and HIV in Uganda

  A mobile health program is being tested to help people with HIV in Uganda manage depression, anxiety, alcohol use, and high blood pressure alongside HIV care.

  NIH research Yale University · New Haven, United States · NIH-11590736

• mHealth plan to help HIV patients in Uganda manage mental health, blood pressure, and HIV together

  A mobile-health approach is being tested to help people living with HIV in Uganda manage depression, anxiety, alcohol use, and high blood pressure alongside HIV care.

  NIH research Yale University · New Haven, United States · NIH-11590735

• Non-viral CRISPR delivery to treat Angelman syndrome and related neurodevelopmental disorders

  A new, non-viral gene editing delivery system is being developed to target brain cells and potentially treat Angelman syndrome and related neurodevelopmental disorders.

  NIH research Yale University · New Haven, United States · NIH-11582654

• Schoolyard upgrades to reduce youth violence in NYC

  A project in New York City tests whether turning schoolyards into safer, more inviting places to play after school and on weekends lowers violent incidents among kids and young adults aged 10–24.

  NIH research Yale University · New Haven, United States · NIH-11582514

• R3EDI: Faster, clearer ways to bring AIDS/ HIV care improvements into real life

  A nationwide implementation science grant to help turn proven HIV care improvements into everyday practice across many settings.

  NIH research Yale University · New Haven, United States · NIH-11578661

• Peer-delivered, family-engaged brief interventions to prevent youth suicide in Nepal

  A pilot program in Nepal tests a teen-friendly, low-cost plan to use peers and family support to prevent suicide among youth aged 12–24.

  NIH research Yale University · New Haven, United States · NIH-11575270

• Peer-delivered and family-supported brief interventions to prevent youth suicide in Nepal

  A pilot program in Nepal tests brief, youth-friendly interventions delivered by peers and supported by families to reduce suicide risk among 12–24 year-olds.

  NIH research Yale University · New Haven, United States · NIH-11575267

• Mu and Kappa Opioid Balance in Alcohol Use Disorder

  A study using brain imaging to understand how the brain’s opioid system changes during early sobriety in adults with alcohol use disorder.

  NIH research Yale University · New Haven, United States · NIH-11564204

• How genetic diversity in malaria relates to vaccine candidates

  A malaria vaccine project at Yale looks at how differences in the parasite’s genes affect how well vaccine candidates might work in diverse populations.

  NIH research Yale University · New Haven, United States · NIH-11557209

• SUSTAIN 2: A patient-centered plan to keep people with HIV in care in South Africa

  A program tests a patient-centered care model to help people with HIV in South Africa stay connected to care and keep their virus under control.

  NIH research Yale University · New Haven, United States · NIH-11556548

• Persistent vascular problems and thinking skills in people with HIV who are virally suppressed

  This project tests whether ongoing blood vessel problems are linked to thinking and memory in older people with HIV who have controlled virus levels.

  NIH research Yale University · New Haven, United States · NIH-11555632

• Decentralizing HIV Care from Specialty Clinics to Primary Centers in Peru

  Aimed at making HIV care more convenient and consistent by moving services from big clinics to local primary care centers in Peru, with lessons that could also help the U.S. healthcare system.

  NIH research Yale University · New Haven, United States · NIH-11552148

• Gut-brain links in food allergy responses

  A research grant is exploring how signals between the gut and brain drive dangerous reactions to foods, with the goal of helping people with food allergies.

  NIH research Yale University · New Haven, United States · NIH-11551492

• STOP HIV care in people involved with the criminal legal system

  A multi-year program to help people who are involved with the criminal legal system access PrEP, ART, and substance use treatment in ways that fit their needs.

  NIH research Yale University · New Haven, United States · NIH-11550838

• eDyNAmiC: Understanding and Targeting ecDNA in Cancer

  A Yale-led project will study circular extrachromosomal DNA in cancers to understand how it drives aggressive tumors and how it might be targeted for better treatments.

  NIH research Yale University · New Haven, United States · NIH-11539608

• Peer-led TB-HIV Education and Adherence Support in Uganda

  A group of trained peers helps people with TB and TB-HIV in Uganda stick to treatment and stay informed, with results studied across several clinics in a large, real-world trial.

  NIH research Yale University · New Haven, United States · NIH-11538516

• CatSper and calcium signaling in sperm fertility

  A study at Yale investigates how a sperm channel called CatSper helps calcium signaling to drive sperm movement and fertility in mammals.

  NIH research Yale University · New Haven, United States · NIH-11537879

• Team science approach to study aging and Alzheimer’s disease with machine learning and functional genomics

  A combined team effort will use advanced computer models and brain cell data to understand how aging influences Alzheimer’s disease.

  NIH research Yale University · New Haven, United States · NIH-11537711

• Genetics study of methamphetamine use disorder in Thai people

  A genetics study in Thailand is looking at how genes may influence methamphetamine use disorder and related behaviors.

  NIH research Yale University · New Haven, United States · NIH-11535768

• Healthy Families-PrEP: helping women in Uganda start and stay on PrEP during periconception, pregnancy, and postpartum

  A program in Uganda helps periconception, pregnant, and postpartum women use PrEP safely to prevent HIV, with support sessions and monitoring.

  NIH research Yale University · New Haven, United States · NIH-11533806

Quick answers

How many clinical trials run by Yale University are recruiting right now?

233, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (224 trials), Uganda (4 trials), Canada (2 trials), Kyrgyzstan (2 trials), Tajikistan (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 49, Phase 1: 24, Early Phase 1: 12, Phase 4: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →