Exercise program for adults with primary antibody deficiencies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study is an interventional, single-arm exploration of a 12-week, app-based exercise program for adults with primary antibody deficiency disorders. Participants will complete health questionnaires, log exercise activity via a mobile app, have their symptoms tracked, provide blood samples for immune-related tests, and undergo assessments at baseline and after 12 weeks. The program will screen participants using ACSM guidelines to ensure suitability for moderate-intensity exercise. Data will be collected to evaluate safety, feasibility, tolerability, and potential impacts on quality of life and immune health. Led by Yale University and conducted with collaborators at The Pump and partner sites in Connecticut.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with one of the following primary antibody deficiencies: IgG subclass deficiency, selective IgA deficiency, selective IgM deficiency, or specific antibody deficiency
* Receiving care in the Section of Rheumatology, Allergy \& Immunology
* Able and willing to participate in a moderate-intensity exercise program. Patients will be screened using the American College of Sports Medicine (ACSM) Pre- participation Screening Guidelines. This algorithm assesses patients for cardiovascular, renal, and metabolic disease. Those patients determined to not require further medical clearance to participate in exercise will be included.

Exclusion Criteria:

* Receipt of immunoglobulin (Ig) replacement therapy
* Use of immunosuppressive or immunomodulatory medications (e.g., chronic systemic corticosteroids, B-cell-depleting therapies)
* Medical contraindications to moderate-intensity exercise as determined by clinical assessment using the previously discussed ACSM Pre-participation Screening Guidelines.
* Other risk factors/medical conditions that would limit safe participation in exercise as determined by clinical assessment, including active rheumatologic conditions including active rheumatoid arthritis.

Where it's running

• Bridgeport Hospital
  Milford, Connecticut, United States Recruiting
• Yale New Haven Health
  North Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Ryan Steele, DO, MSc — Yale University
• Study coordinator: Ryan Steele, DO, MSc
• Email: r.steele@yale.edu
• Phone: 203-785-7092

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.