Healthy Families-PrEP: helping women in Uganda start and stay on PrEP during periconception, pregnancy, and postpartum
Official title: Evaluating Healthy Families PrEP: an intervention to promote PrEP use during periconception, pregnancy, and postpartum periods for women in rural Uganda
Funded at Yale University · NIH-11533806 · Data updated 2026-11-12
A program in Uganda helps periconception, pregnant, and postpartum women use PrEP safely to prevent HIV, with support sessions and monitoring.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 10, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $229,855 |
| NIH project number | 3R01MH134680-02S1 |
| Project ID | NIH-11533806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women in Uganda who are periconception, pregnant, or up to postpartum with interest in PrEP and access to HIV care.
✕Less likely to help
Women not considering PrEP or not seeking care in the study setting may not benefit from the intervention.
What this research studies
This project builds on a successful 3-session Healthy Families-PrEP program previously tested in an HIV care clinic. It will adapt and test the intervention in community care settings in Uganda to reduce HIV incidence among women planning pregnancy and those who are pregnant or postpartum. Participants receive counseling, PrEP access, and quarterly adherence support, with dose monitoring to ensure protective use. The research aims to generate evidence that could later be applied in the U.S. to improve PrEP uptake and adherence for perinatal women.
Why it matters
Potential benefit: If successful, the intervention could reduce new HIV infections among periconception, pregnant, and postpartum women and guide scalable PrEP support programs.
How similar studies have gone: Pilot data showed high PrEP initiation and adherence, supporting further testing in real-world settings.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Matthews, Lynn T — Yale University
- Study coordinator: Matthews, Lynn T
Related research
Other NIH-funded projects on the same topics.
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Healthy Families-PrEP: helping pregnant and new mothers in Uganda stay HIV-free
A family-focused program in Uganda tests an approach to help women who are planning pregnancy or are pregnant or postpartum use PrEP to prevent HIV infection.
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LA-MOM: Long-Acting HIV ART in Pregnancy and After Birth
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Injectable HIV PrEP in maternity clinics to protect pregnant and postpartum women
A doctor-scientist team is testing a twice-yearly injectable HIV prevention medicine for pregnant and postpartum women in high-risk areas to help keep them and their babies HIV-free.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.