Clinical trial Recruiting at 1 site Interventional Ages 18 to 40

Testing a new model for learning and retaining speech motor skills

Official title: Sensorimotor Basis of Speech Motor Learning and Retention

Run by Yale University · NCT06467292 · Data updated 2026-11-12

This study is testing a new way to help people learn and remember how to speak by looking at how different parts of the brain work together during speech practice.

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexAll
Enrollment330 (estimated)
SponsorYale University
Academic / other
Locations1 site (New Haven, Connecticut)
StatusRecruiting
StartedOctober 1, 2024
Main results expectedNovember 30, 2028
Study endsMay 31, 2029
Registry record updatedAugust 18, 2026
Trial IDNCT06467292 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are fluent English-speaking, right-handed individuals with normal hearing and no speech disorders.

Probably not a fit

Patients with neurological disorders, metal implants, or those on psychoactive medications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to explore a novel model of speech motor learning, focusing on how learning and retention are influenced by brain plasticity in motor, auditory, and somatosensory regions. The study consists of three main aims: the first tests speech motor memory retention after disrupting brain activity in specific areas, the second examines the sequence of plasticity in these brain regions during speech learning, and the third utilizes resting-state fMRI alongside speech motor adaptation. Continuous theta-burst stimulation (cTBS) and other interventions will be employed to assess their effects on learning retention.

Why it matters

Potential benefit: If successful, this study could enhance therapeutic approaches for individuals with speech motor challenges by improving learning and retention of speech skills.

How similar studies have gone: Other studies have shown promise in using brain stimulation techniques for speech motor learning, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Fluent English speakers
* Right-handed
* Normal hearing
* No speech disorder or reading disability

Exclusion Criteria:

* Cardiac pacemaker
* Aneurysm clip
* Heart or Vascular clip
* Prosthetic valve
* Metal implants
* Metal in brain, skull, or spinal cord
* Implanted neurostimulator
* Medication infusion device
* Cochlear implant or tinnitus (ringing in ears)
* Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
* Psychoactive medications
* Pregnancy

Where it's running

  • Yale Child Study Center
    New Haven, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.