Non-invasive central venous pressure estimation using an external jugular venous occlusion device

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, single-arm, investigator-blinded feasibility study will enroll adult CICU patients who already have invasive central venous pressure/right atrial monitoring. Each participant will have concurrent non-invasive external jugular venous occlusion pressure measurements taken with the CPMX2 device while standard invasive CVP readings are recorded. The study compares the non-invasive and invasive measurements within the same patients to gather preliminary data on safety, feasibility, and accuracy. Key exclusions include positive-pressure ventilation, non-visible external jugular veins, bilateral venous thrombosis, and neck skin lesions or dressings that prevent device placement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of signed and dated informed consent
* Admitted to the CICU with invasive CVP/RA pressure monitoring placed by standard of care as determined by the treating team before enrollment
* No more than moderate TR as assessed by echocardiogram

Exclusion Criteria:

* Undergoing positive pressure ventilation (Bipap or invasive mechanical ventilation)
* Non-visible external jugular vein bilaterally (by visual examination or with traditional ultrasound examination)
* History of thrombosis in any of the following vessels bilaterally; external jugular vein, internal jugular vein, brachiocephalic vein or superior vena cava
* Skin lesions, vascular access sites or dressings covering neck and impeding access to the external jugular veins at the level of the muscle belly of the sternocleidomastoid muscle

Where it's running

• Yale New Haven Hospital CICU
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Mark Jacobs, MD MBA MS — Yale University
• Study coordinator: Mark Jacobs, MD MBA MS
• Email: mark.jacobs@yale.edu
• Phone: 203-688-2176

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.