Portable MRI to detect brain injury after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares low-field portable MRI performed at the bedside with conventional high-field MRI to measure the severity of hypoxic-ischemic brain injury after cardiac arrest. Investigators will obtain early portable MRI scans within 6 and 24 hours after return of spontaneous circulation and perform serial imaging over subsequent days to track injury evolution. The study measures inter-rater agreement between readers and the specificity and positive predictive value of early diffusion-weighted imaging lesions versus conventional MRI and clinical outcomes. Enrollment is at a single center and focuses on adults receiving temperature control who are unresponsive after cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Unresponsive immediately after ROSC from IHCA or OHCA
* Age ≥ 18 years of age
* Conventional MRI is clinically indicated
* Treatment with temperature control

Exclusion Criteria:

* MRI contraindication according to the American Heart Association guidelines
* Inability to tolerate supine positioning for 30 minutes
* Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC

Where it's running

• Yale New Haven Hospital
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Rachel Beekman, MD — Yale University
• Study coordinator: Rachel Beekman, MD
• Email: rachel.beekman@yale.edu
• Phone: 516-965-4251

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.