Preoperative submaximal exercise testing to predict outcomes after moderate- to high-risk noncardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective observational cohort collects routinely obtained brief submaximal cardiopulmonary exercise testing (smCPET) data from adults presenting to a pre-surgical evaluation clinic and links those measurements to perioperative outcomes. Researchers will combine exercise-derived physiologic measures with clinical, perioperative, and postoperative outcome data to see whether smCPET variables relate to complications within 30 and 60 days, length of stay, and mortality. No additional testing or interventions are performed for the research; all data come from routine care and chart review, with a retrospective validation component. The repository is designed to support development of scalable perioperative risk models that could be applied in future implementation studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* greater than 45 years old
* moderate to high-risk noncardiac surgery
* surgeon, anesthesiologist or other medical provider requested referral for preoperative high risk evaluation, or
* revised cardiac risk index \> or = 2, or
* Ambiguous, low or discordant functional capacity by either the Duke Activity status index (DASI \<34) or the modified Duke Activity status index (\< or =3) or
* Frailty Index \>1

Exclusion Criteria:

* Age \<45
* Absolute contraindication to submaximal cardiopulmonary exercise testing
* Impaired decision making capacity
* Prisoners
* Pregnancy
* Severe peripheral vascular disease
* Functional limitation precluding the performance of submaximal cardipulmonary exercise testing
* Severe active pulmonary disease

Where it's running

• Yale New Haven Hospital, Pre-Surgical Evaluation Clinic
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Zyad J Carr, M.D. — Yale University
• Study coordinator: Zyad J Carr, M.D.
• Email: zyad.carr@yale.edu
• Phone: 203.785.3689

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.