Neurofeedback for managing food cravings in overweight individuals
Official title: Connectome-based Neurofeedback of the Craving Network to Reduce Food Cue Reactivity
Run by Yale University · NCT06426693 · Data updated 2026-11-12
This study tests if neurofeedback can help overweight people with strong food cravings change how their brains respond to food and improve their eating habits.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Yale University Academic / other |
| Locations | 1 site (New Haven, Connecticut) |
| Status | Recruiting |
| Started | November 27, 2024 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | December 3, 2025 |
| Trial ID | NCT06426693 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 60 with a body mass index over 25 and significant food cravings.
✕Probably not a fit
Patients currently using anti-obesity medications, experiencing significant weight loss recently, or having neurological or psychiatric disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project investigates whether individuals with overweight or obesity and high food cravings can learn to modify their brain responses to food cues through neurofeedback. The study has three main aims: to assess if neurofeedback from the craving network reduces craving network strength, to evaluate its impact on food cravings and eating behaviors, and to examine changes in resting state functional connectivity. Participants will receive either experimental or control feedback during the intervention.
Why it matters
Potential benefit: If successful, this approach could help individuals better manage their cravings and improve their eating behaviors, potentially leading to weight loss.
How similar studies have gone: Other studies have shown promise in using neurofeedback for behavioral modifications, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18 to 60 years * Body mass index \>25 kg/m2 * \>2.37 Food Craving Inventory score Exclusion Criteria: * Current or past 6 months use of anti-obesity medications * Weight-reduced state defined as \>10% weight reduction in the past 6 months. * Nicotine use * Current diagnosis of neurological or psychiatric disorder * Obesity-related diseases such as type-2 diabetes * Contraindications to MRI * Baseline scanning with motion \>0.15mm frame to frame displacement.
Where it's running
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Yale MRRC Anlyan Center
New Haven, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Kathleen A Garrison, PhD — Yale University
- Study coordinator: Kathleen A Garrison, PhD
- Email: kathleen.garrison@yale.edu
- Phone: 2037376232
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.