Clinical trial Recruiting at 1 site Interventional Ages 18 to 60

Neurofeedback for managing food cravings in overweight individuals

Official title: Connectome-based Neurofeedback of the Craving Network to Reduce Food Cue Reactivity

Run by Yale University · NCT06426693 · Data updated 2026-11-12

This study tests if neurofeedback can help overweight people with strong food cravings change how their brains respond to food and improve their eating habits.

More Overweight or Obesity trials

Quick facts

Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment50 (estimated)
SponsorYale University
Academic / other
Locations1 site (New Haven, Connecticut)
StatusRecruiting
StartedNovember 27, 2024
Main results expectedMarch 31, 2027
Study endsMarch 31, 2027
Registry record updatedDecember 3, 2025
Trial IDNCT06426693 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 60 with a body mass index over 25 and significant food cravings.

Probably not a fit

Patients currently using anti-obesity medications, experiencing significant weight loss recently, or having neurological or psychiatric disorders may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates whether individuals with overweight or obesity and high food cravings can learn to modify their brain responses to food cues through neurofeedback. The study has three main aims: to assess if neurofeedback from the craving network reduces craving network strength, to evaluate its impact on food cravings and eating behaviors, and to examine changes in resting state functional connectivity. Participants will receive either experimental or control feedback during the intervention.

Why it matters

Potential benefit: If successful, this approach could help individuals better manage their cravings and improve their eating behaviors, potentially leading to weight loss.

How similar studies have gone: Other studies have shown promise in using neurofeedback for behavioral modifications, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Ages 18 to 60 years
* Body mass index \>25 kg/m2
* \>2.37 Food Craving Inventory score

Exclusion Criteria:

* Current or past 6 months use of anti-obesity medications
* Weight-reduced state defined as \>10% weight reduction in the past 6 months.
* Nicotine use
* Current diagnosis of neurological or psychiatric disorder
* Obesity-related diseases such as type-2 diabetes
* Contraindications to MRI
* Baseline scanning with motion \>0.15mm frame to frame displacement.

Where it's running

  • Yale MRRC Anlyan Center
    New Haven, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.