Parent-led programs to help teens with anxiety

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial assigns families to one of two parent-based interventions (SPACE or PES) delivered in 12 weekly sessions with a mid-treatment and post-treatment assessment plus a follow-up. Primary outcome measures are adolescent anxiety symptoms collected via questionnaires and clinical interviews, and secondary outcomes include family accommodation and overall family functioning. Sessions may be attended in person or via Zoom, and parents are the direct recipients of the interventions while adolescents are assessed for symptom change. The trial excludes adolescents with more impairing comorbid disorders and requires a willing, eligible participating parent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet criteria for a primary DSM-5 AD, including separation anxiety disorder, social anxiety disorder, generalized anxiety disorder, specific phobia, panic disorder, and agoraphobia (determined by the ADIS-C/P).
* Cease all other psychosocial treatment, upon consultation with the project staff and service provider.
* Not currently use any psychotropic medication, other than a stable dose (i.e., same dose for a minimum of 6 months prior to enrollment; no changes during course of the study) of a stimulant medication or selective serotonin reuptake inhibitor (SSRI).
* Have an eligible and willing participating parent (see parent exclusions below).

Exclusion Criteria:

Adolescent:

* Meet criteria for any DSM-5 disorder more impairing than the most impairing AD (determined by the ADIS-C/P).
* Have any of the following disorders: autism spectrum disorder; intellectual disability; neurocognitive disorders; bipolar disorder; schizophrenia and other psychotic disorders; and alcohol and substance use disorders (determined by the Health History Form and ADIS-C/P).
* Report a suicide attempt in the last 3 months, or current suicide intent and plans (determined by the ASQ).
* Be a victim of past or present undisclosed abuse requiring investigation or ongoing supervision by the Department of Social Services.
* Not have sufficient proficiency with the English language to complete assessments.

Parents:

* Have any of the following: intellectual disability; neurocognitive disorders; untreated bipolar disorder; untreated schizophrenia and other psychotic disorders; and untreated alcohol and substance use disorders (determined by the Health History Form).
* Not be living with the adolescent at least 50% of the time for at least one year prior to enrollment.
* Not have sufficient proficiency with the English language to complete assessments and treatment.

Where it's running

• Yale Child Study Center
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Rebecca Etkin, PhD — Yale University
• Study coordinator: Rebecca Etkin, PhD
• Email: Rebecca.etkin@yale.edu
• Phone: 203-737-4644

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.