Transcranial direct current stimulation for laryngeal dystonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will undergo baseline MRI and EEG recordings and then attend multiple testing sessions across five days. People with laryngeal dystonia will receive 20 minutes of high-definition tDCS (HD-tDCS) via the Starstim system while watching videos or performing a word-production task. Stimulation will be applied to several brain regions thought to be involved in voice control to alter neural activity. Outcomes will compare voice measures and neuroimaging/EEG signals before and after the stimulation protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
* No other known or history of speech, voice disorder other than LD.
* Provision of signed and dated informed consent form.
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Must not be pregnant.

Exclusion Criteria:

* All individuals who do not meet the above mentioned criteria are excluded from the study.
* Subjects with a history of epilepsy or depression or is claustrophobic.

Where it's running

• Yale University
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Nabin Koirala, PhD — Yale University
• Study coordinator: Nabin Koirala, PhD
• Email: nabin.koirala@yale.edu
• Phone: 203 7852527

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How gentle vibration to the throat affects brain activity in people with laryngeal dystonia

  This study will test whether a short session of noninvasive vibro-tactile stimulation to the larynx can improve voice symptoms and alter brain network activity in adults with laryngeal dystonia.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07443891

• Deep Brain Stimulation for treating laryngeal dystonia

  This study is testing if Deep Brain Stimulation can help people with Adductor Laryngeal Dystonia improve their vocal function.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05506085

• Examining brain function in laryngeal dystonia and voice tremor

  This study is testing how brain function differs in people with laryngeal dystonia and voice tremor compared to healthy individuals to better understand these voice disorders.

  Recruiting Early Phase 1 Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05216770

• Evaluating voice disorders like laryngeal dystonia and voice tremor

  This study is testing new ways to tell the difference between laryngeal dystonia and voice tremor to help people get the right treatment for their voice disorders.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05150106

• Deep Brain Stimulation for Voice Disorders in Dystonia and Tremor

  This study is testing if deep brain stimulation can improve voice problems in people with laryngeal dystonia and essential tremor.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05150093

• Neuromodulation effects on laryngeal dystonia

  This study is testing if a brain stimulation treatment can help people with laryngeal dystonia improve their voice and overall quality of life.

  Recruiting MGH Institute of Health Professions · Boston, Massachusetts · NCT05095740

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.