Persistent vascular problems and thinking skills in people with HIV who are virally suppressed
Official title: Persistent Vascular Dysfunction and Cognition among Virally Suppressed People with HIV
Funded at Yale University · NIH-11555632 · Data updated 2026-11-12
This project tests whether ongoing blood vessel problems are linked to thinking and memory in older people with HIV who have controlled virus levels.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $78,607 |
| NIH project number | 3R21TW012880-02S1 |
| Project ID | NIH-11555632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 50+ with stable HIV on ART and a demographically matched HIV-negative control group, residing in or able to travel to Bangkok for assessments.
✕Less likely to help
Individuals not meeting age, HIV status, or ART-stability criteria may not benefit from this study.
What this research studies
Among adults aged 50 and older with HIV who have stable antiretroviral therapy, researchers will measure blood biomarkers, eye-based microvascular health using OCTA, and cognitive performance. They will compare 200 virally suppressed people with HIV to 50 similar individuals without HIV in Bangkok, Thailand, to see how vascular health relates to cognition. The study integrates biomarker data, eye imaging, and comprehensive cognitive tests to identify patterns and subgroups. This work leverages HIVNAT’s established cohorts and laboratory capabilities to explore potential mechanisms connecting immune activation, blood vessel function, and thinking abilities.
Why it matters
Potential benefit: If successful, the findings could help identify markers and targets for preventing cognitive problems in people living with HIV.
How similar studies have gone: Previous related work has shown links between vascular health and cognition in diverse populations, but this specific HIV-suppressed, older cohort is novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Chan, Yin Cheung Phillip — Yale University
- Study coordinator: Chan, Yin Cheung Phillip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.