Comparing e-cigarettes and nicotine pouches for reducing cigarette smoking

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to recruit 256 adult smokers who are willing to switch to alternative, non-combustible products. Participants will be randomly assigned to use either e-cigarettes or nicotine pouches over a 4-week period, with variations in flavor availability and nicotine concentration. They will attend bi-weekly visits to monitor their smoking behaviors and product usage, culminating in a follow-up at Week 6 to evaluate the effectiveness of the products in reducing cigarette consumption. The study is designed to identify which product characteristics are most effective in promoting smoking reduction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 21+ years old
* English literate
* Currently smoking cigarettes, biochemically confirmed

Exclusion Criteria:

* Currently using smoking cessation pharmacotherapies (NRT, bupropion, varenicline)
* Currently pregnant or breastfeeding
* Significant current medical or psychiatric condition
* Known hypersensitivity to propylene glycol

Where it's running

• Yale University
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Lisa Fucito, PhD — Yale University
• Study coordinator: Lisa M. Fucito, PhD
• Email: lisa.fucito@yale.edu
• Phone: 203-200-1470

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.