CREBRF gene and diabetes risk in American Samoan pregnancies
Official title: CREBRF and risk of pregnancy and postpartum dysglycemia in American Samoan women
Funded at Yale University · NIH-11592385 · Data updated 2026-11-12
This project follows 350 pregnant American Samoan women to understand how a specific gene variant may influence diabetes risk during and after pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 19, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $168,378 |
| NIH project number | 3R01DK139672-03S1 |
| Project ID | NIH-11592385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant American Samoan women enrolled in the first trimester who consent to genetic and metabolic testing and follow-up through 18 months postpartum.
✕Less likely to help
Women who do not carry the CREBRF risk or protective variant may not experience changes in their care based on this study.
What this research studies
A cohort of 350 expectant American Samoan women will be enrolled in the first trimester and tracked through pregnancy and up to 18 months after birth to study how the CREBRF gene variant relates to gestational diabetes and postpartum diabetes risk. Researchers will collect genomic data, biometrics, and metabolic measurements at several time points (early pregnancy, mid-to-late pregnancy, and postpartum) to explore insulin secretion and diabetes pathways. The study aims to identify whether the CREBRF variant changes diabetes risk and how it could guide earlier screening and prevention efforts in this population. Findings could inform personalized care strategies for women at risk of diabetes after pregnancy, particularly in communities with high diabetes burden.
Why it matters
Potential benefit: If successful, the research could lead to better screening and prevention plans for diabetes in American Samoan women before and after pregnancy.
How similar studies have gone: Prior work has linked CREBRF variants to body mass and diabetes risk, with ongoing questions about its role in gestational and postpartum diabetes.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Hawley, Nicola — Yale University
- Study coordinator: Hawley, Nicola
Related research
Other NIH-funded projects on the same topics.
-
Healthy Families-PrEP: helping women in Uganda start and stay on PrEP during periconception, pregnancy, and postpartum
A program in Uganda helps periconception, pregnant, and postpartum women use PrEP safely to prevent HIV, with support sessions and monitoring.
-
Healthy Families-PrEP: helping pregnant and new mothers in Uganda stay HIV-free
A family-focused program in Uganda tests an approach to help women who are planning pregnancy or are pregnant or postpartum use PrEP to prevent HIV infection.
-
LA-MOM: Long-Acting HIV ART in Pregnancy and After Birth
This study follows pregnant people with HIV who receive long-acting injectable HIV medicines to understand how the drugs behave in the body, how they reach the baby, and what patients experience during pregnancy and after birth.
-
Effects of prescription opioid use during pregnancy on a mother's brain after birth
This project looks at how taking prescription opioids during pregnancy changes a mother's brain and behavior after her baby is born.
-
PrEP in Pregnancy and Postpartum Data Hub
A patient-friendly data-sharing project that brings together information from many pregnancy and postpartum PrEP studies to better understand HIV prevention for mothers and their babies.
-
Family sodium reduction program for new mothers with hypertensive pregnancy disorders
A postpartum care program helps women with hypertensive disorders of pregnancy reduce salt in their diet to lower blood pressure and protect heart health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.