Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care
Official title: Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
Run by Yale University · NCT07639060 · Data updated 2026-11-12
This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Yale University Academic / other |
| Locations | 1 site (Old Saybrook, Connecticut) |
| Status | Recruiting |
| Started | June 20, 2026 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07639060 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with chronic pain lasting at least 3–6 months, for whom cryoneurolysis is planned as part of standard care and who can consent and complete follow-up.
✕Probably not a fit
Patients unlikely to benefit include those with contraindications to cryoneurolysis, a life expectancy under 12 months, or conditions that preclude reliable follow-up.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational prospective study conducted at Yale that follows patients who receive cryoneurolysis as part of their usual clinical care for chronic pain. The goal is to describe patient-centered outcomes and health care utilization over 12 months. Eligible patients have chronic pain in regions suitable for cryoneurolysis and can provide consent and complete questionnaires. Data are collected through routine clinical practice without a centralized intervention beyond the cryoneurolysis procedure. Results will reflect real-world experiences in a single academic-affiliated center.
Why it matters
Potential benefit: If successful, the study could clarify how cryoneurolysis impacts pain, function, and health care use over a year.
How similar studies have gone: Prior observational work in similar settings suggests potential benefits, but results may vary by patient and target nerve.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician. * Planned cryoneurolysis procedure as part of standard clinical care. * Ability to provide written informed consent. * Ability and willingness to complete baseline and follow-up questionnaires. Exclusion Criteria: * Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted. * Active infection or other clinical contraindication to the procedure as determined by the treating clinician. * Life expectancy of less than 12 months in the judgment of the treating clinician. * Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up
Where it's running
-
Yale New Haven Health Old Saybrook Medical Center
Old Saybrook, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Charles A Odonkor, MD — Yale University
- Study coordinator: Charles A Odonkor, MD
- Email: charles.odonkor@yale.edu
- Phone: 203-767-1555
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.