Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
Official title: Aging Well with HIV through Alcohol Research and Risk Reduction and Education (AWAR3E) Center
Funded at Yale University · NIH-11638490 · Data updated 2026-11-12
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 10, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $162,030 |
| NIH project number | 3P60AA032190-02S1 |
| Project ID | NIH-11638490 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with HIV, especially those who use alcohol or are socioeconomically disadvantaged, may be eligible to participate across the four cohorts involved.
✕Less likely to help
Individuals without HIV or who are not within the target cohorts may not directly benefit from these specific studies.
What this research studies
This NIH-funded center brings together four HIV cohorts to study inflammaging in people with HIV. Researchers will look for biomarkers like methylation age, HIV reservoirs, and immune system signals to understand aging-related inflammation. They will also examine how long-acting HIV medications and GLP-1 receptor agonists might counteract these aging processes. The work aims to identify which patients are most affected and how to reduce geriatric syndromes such as falls, delirium, and frailty.
Why it matters
Potential benefit: If successful, the work could lead to better ways to monitor aging in people with HIV and new strategies to prevent frailty and related health problems.
How similar studies have gone: Previous studies have shown inflammation and aging processes differ in people with HIV, supporting the potential for meaningful advances in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Justice, Amy Caroline — Yale University
- Study coordinator: Justice, Amy Caroline
Related research
Other NIH-funded projects on the same topics.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
-
Understanding TDP43 Mislocalization in Aging and ALS-FTLD-LATE
Researchers are studying how the TDP43 protein misfolds and clumps in aging brains, to help people with ALS and related disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.